Influence of serum lipids on the incidence and progression of diabetic retinopathy and macular oedema: Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular genetics Study-II

Clinical & Experimental Ophthalmology
Sangeetha SrinivasanTarun Sharma

Abstract

The importance of lipids on incidence and progression of diabetic retinopathy has not been studied in the Indian population. To elucidate the influence of serum lipid control on the incidence and progression of diabetic retinopathy and diabetic macular oedema in subjects with type 2 diabetes. Population-based longitudinal observational study in a hospital setting. Eight hundred ninety subjects were examined at baseline and follow-up. Diabetic retinopathy was graded per Modified Early Treatment Diabetic Retinopathy Study scales; 45°, 4-field dilated stereoscopic digital photography was performed with an additional 30°, 7-field for those who had retinopathy. Macular oedema was evaluated per Proposed International Clinical Diabetic Retinopathy and Diabetic Macular Oedema Disease Severity Scales. Association of serum lipids and incidence and progression of diabetic retinopathy. Poor control of total cholesterol was associated with the incidence of sight-threatening retinopathy (odds ratio = 7.2 [95% confidence interval: 1.5-34.3], P = 0.012) and macular oedema (odds ratio = 5.5 [95% confidence interval: 1.4-27.4], P = 0.037) after adjusting for potential confounders. Poor control of triglycerides was associated with progression to ...Continue Reading

References

Sep 1, 1986·Ophthalmology·R KleinM D Davis
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Timothy J LyonsRichard L Klein
Oct 27, 2004·Diabetes·Biljana MiljanovicDebra A Schaumberg
Aug 23, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·M RemaV Mohan
Apr 27, 2007·Annals of the New York Academy of Sciences·Nil Irem UçgunEmin Gürsel
Jun 29, 2010·Lancet·Ning CheungTien Yin Wong
Jul 1, 2010·The New England Journal of Medicine·UNKNOWN ACCORD Study GroupLawrence J Fine
Aug 25, 2011·Investigative Ophthalmology & Visual Science·Rehab BenarousEcosse L Lamoureux
Jul 13, 2013·Investigative Ophthalmology & Visual Science·Mariko SasakiJie Jin Wang
Aug 31, 2014·Ophthalmology·Emily Y ChewUNKNOWN Action to Control Cardiovascular Risk in Diabetes Eye Study Research Group
May 11, 2016·Middle East African Journal of Ophthalmology·Gunjan PrakashShikha Prakash

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Citations

Sep 12, 2019·Current Diabetes Reports·Avinash HonasogeRithwick Rajagopal
Aug 3, 2019·The International Journal of Health Planning and Management·Fei QinRong Shi
Jan 8, 2021·International Journal of Environmental Research and Public Health·Tsai-Tung ChiuChao-Hsien Lee
Feb 4, 2021·Endocrinology, Diabetes & Metabolism·Sangeetha SrinivasanRajiv Raman

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