Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study

Journal of Hypertension
Heiner K BertholdIoanna Gouni-Berthold

Abstract

Selenium is an antioxidant micronutrient with potential associations with hypertension. Few studies have investigated the association of serum selenium concentrations with blood pressure and hypertension in countries with low dietary selenium intake such as Germany, with inconsistent findings. We undertook a cross-sectional analysis of participants in the Lipid Analytic Cologne (LIANCO) cohort. To reduce potential confounding, we restricted the analysis to 792 participants who were never smokers, who did not use antihypertensive medications, and who did not have diabetes or known atherosclerotic disease. Hypertension was defined as blood pressure at least 140 and/or at least 90  mmHg. About half of the cohort was diagnosed as hypertensive. Selenium was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry (ICP-DRC-MS). Mean ± standard deviation (SD) serum selenium concentration was 68  ±  32 μg/l. The multivariable adjusted differences (95% confidence intervals) in blood pressure levels comparing the highest (>91.9 μg/l) to the lowest (≤ 42.8 μg/l) quartile of serum selenium were 5.2 (1.4 to 8.9), 2.8 (0.7 to 4.8), and 2.4 (-0.4 to 5.2) mmHg for systolic, diastolic, and pulse pressure, respectively (P f...Continue Reading

References

Nov 1, 1988·The American Journal of Clinical Nutrition·J T SalonenR Rauramaa
Aug 1, 1985·American Journal of Epidemiology·J VirtamoM J Karvonen
Dec 15, 1995·The American Journal of Cardiology·S SalviniM J Stampfer
Oct 28, 1999·The American Journal of Clinical Nutrition·A J DuffieldS Williams
Jun 3, 2000·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A M Viegas-CrespoJ Nève
Aug 30, 2000·Lancet·M P Rayman
May 12, 2001·The British Journal of Nutrition·G F Combs
Jan 5, 2002·The New England Journal of Medicine·B G BrownJ J Albers
May 21, 2003·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mohammad R Kafai, Vijay Ganji
Oct 24, 2003·The New England Journal of Medicine·Stefan BlankenbergUNKNOWN AtheroGene Investigators
Aug 19, 2004·Cellular and Molecular Life Sciences : CMLS·L SchomburgJ Köhrle
Feb 17, 2005·The Science of the Total Environment·Andrea BatáriováJirí Smíd
Sep 20, 2005·Annals of Clinical Biochemistry·M Ghayour-MobarhanG A A Ferns
Feb 14, 2006·The British Journal of Nutrition·J ArnaudS Hercberg
Oct 7, 2006·The American Journal of Clinical Nutrition·Gemma Flores-MateoEliseo Guallar
Jan 24, 2007·European Heart Journal·Tim S NawrotHarry A Struijker-Boudier
Mar 30, 2007·Diabetes Care·Joachim BleysEliseo Guallar
Jul 11, 2007·Annals of Internal Medicine·Saverio StrangesMary E Reid
Jul 11, 2007·Annals of Internal Medicine·Joachim BleysEliseo Guallar
Nov 6, 2007·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Rudy Van CauwenberghNina Hermans
Jan 17, 2008·Current Opinion in Lipidology·Ana Navas-AcienEliseo Guallar
Feb 27, 2008·Archives of Internal Medicine·Joachim BleysEliseo Guallar
Aug 12, 2008·The American Journal of Clinical Nutrition·Joachim BleysEliseo Guallar
Sep 18, 2008·Biological Trace Element Research·Robyn LymburyAnthony V Perkins
May 1, 2009·The American Journal of Clinical Nutrition·Gerald F CombsBlossom H Patterson
Nov 13, 2009·Antioxidants & Redox Signaling·Laura V PappKum Kum Khanna
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Martin LaclaustraEliseo Guallar
May 18, 2011·Annals of Internal Medicine·Margaret P RaymanEliseo Guallar
Oct 13, 2011·JAMA : the Journal of the American Medical Association·Eric A KleinLaurence H Baker

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Citations

Nov 1, 2013·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Marco VincetiVittorio Krogh
Apr 30, 2015·Nutrients·Carina BenstoemChristian Stoppe
Jul 16, 2014·Free Radical Biology & Medicine·Inmaculada Galan-ChiletF Javier Chaves
May 8, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Geir Bjørklund
Jan 21, 2016·Scientific Reports·Xianlei CaiFudi Wang
Apr 5, 2013·Journal of Hypertension·Ioanna Gouni-BertholdHeiner K Berthold
Feb 16, 2017·Current Hypertension Reports·Sunil K PanchalLindsay Brown
Jul 6, 2018·European Journal of Epidemiology·Marco VincetiKenneth J Rothman
Oct 4, 2018·Current Environmental Health Reports·Marco VincetiLauren A Wise
Sep 17, 2020·Nutrients·Francesc Josep García-GarcíaGlòria Garrabou
Oct 10, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Natalie H MatthewsEunyoung Cho

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