Influence of sex, age, and smoking habits on the urinary excretion of D-glucaric acid

Clinica Chimica Acta; International Journal of Clinical Chemistry
A ColombiV Foà


Reference values for urinary D-glucaric acid and the influence of sex, age and smoking habits were evaluated with a low-pH enzymatic method. D-Glucaric acid measured on spot urine samples from 573 healthy subjects gave mean concentrations (mumol/1) and D-glucaric acid/creatinine ratios (mmol/mol creatinine) of 56.1 (+/- 22.9) and 3.05 (+/- 0.99) for males and 53.3 (+/- 20.9) and 3.35 (+/- 0.95) for females. No difference between morning and evening was observed for urinary D-glucaric acid/1 values, but D-glucaric acid/creatinine was higher in the evening samples for both sexes. There was a negative correlation between D-glucaric acid/1 values and age in males but not in females: the decrease of D-glucaric acid concentration was, however, quantitatively very small. Smoking produced a significant increase in D-glucaric acid concentration and in the D-glucaric acid/creatinine ratio for males and also partially for females.


Jan 1, 1985·International Archives of Occupational and Environmental Health·L AlessioI Ghezzi
Jan 1, 1985·International Archives of Occupational and Environmental Health·R PasquiniG Angeli
Jan 1, 1989·International Archives of Occupational and Environmental Health·R PasquiniG Angeli
Mar 14, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·A ColombiV Foà
Feb 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·L N Sandle, J M Braganza
Jul 1, 1996·Journal of Toxicology and Environmental Health·J P CollinotM M Galteau
Jan 1, 1990·British Journal of Industrial Medicine·A Moretto, M Lotti
Jan 1, 1996·Environmental Health Perspectives·S MonarcaR Pasquini
Oct 8, 1990·Cancer Letters·Zbigniew Walaszek
Jan 1, 1989·Teratogenesis, Carcinogenesis, and Mutagenesis·R PasquiniF Cerami
Jan 1, 2001·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· Maria Luisa Scapellato Giuseppe Mastrangelo Isabella Macca Bruno Saia Giovanni Battista Bartolucci
Mar 24, 2004·Integrative Cancer Therapies·Margaret HanausekThomas J Slaga
Jan 1, 1990·Environmental and Molecular Mutagenesis·R PasquiniP Puccetti
Dec 7, 2018·Archives of Environmental & Occupational Health·Michele A RivaSilvia Fustinoni


Aug 1, 1979·Mutation Research·M A Hamilton, J K Haseman
Aug 1, 1979·British Journal of Clinical Pharmacology·K A MakkiA Richens
Jul 1, 1974·Archives of Environmental Health·D P Morgan, C C Roan
Feb 28, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·C J SimmonsR Williams
Nov 10, 1972·Science·A H Conney, J J Burns
Mar 14, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·A ColombiV Foà
Nov 1, 1980·European Journal of Clinical Pharmacology·K FiedlerH Cramer

Related Concepts

Body Excretions
Glucaric Acid
Excretory Function
Cigar smoker
Circadian Rhythms
Urinary Tract

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