Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry

Clinical Cardiology
Manuel Martínez-SellésJuan Cinca

Abstract

Female sex is an independent predictor of better survival in patients with heart failure (HF), but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence on the cardiovascular system. Sex and previous gestations might have a prognostic impact on 1-year mortality in patients admitted with HF. We conducted an observational, prospective, consecutive, multicenter registry of 1831 patients (756 females [41.2%]) admitted with HF. Females had a more advanced age (75.2 ±11.4 vs 70.4 ±12.2 years), less ischemic heart disease (167 [25.3%] vs 446 [47.3%]), and higher left ventricular ejection fraction (52.0% ±16.6% vs 41.1% ±17.0%) than did men (all P values <0.001). During 1-year follow-up, 373 (20.4%) patients died (151 females and 222 males). Female sex was an independent predictor for survival (hazard ratio: 0.79, 95% confidence interval: 0.64-0.98, P = 0.03). In 504 women (65.9%), the exact number of previous pregnancies could be determined; 62 women (12.3%) had no previous pregnancies, 288 (57.1%) women had 1 or 2 pregnancies, and 154 women (30.6%) had ≥3 pregnancies. We found an association between the number of previous gestations and better survival (hazard ratio: 0.878, 95% confidenc...Continue Reading

References

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Sep 30, 2017·JACC. Heart Failure·Alberto AimoMichele Emdin

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Citations

Jan 30, 2019·European Journal of Preventive Cardiology·Manuel Martínez-Selles
Jan 8, 2021·Frontiers in Cardiovascular Medicine·Andrea Postigo, Manuel Martínez-Sellés
May 1, 2021·Journal of Clinical Medicine·Lourdes VicentManuel Martínez-Sellés
Jul 25, 2021·Journal of Clinical Medicine·Helena Martínez-SellésManuel Martínez-Sellés
Apr 19, 2019·Cardiology·Lourdes VicentManuel Martínez-Sellés

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