PMID: 9431845Feb 12, 1998Paper

Influence of sex on sodium-proton exchange-dependent swelling of platelets from patients with essential hypertension

Journal of Hypertension
P D Stratton, J M Ritter

Abstract

To determine whether sex influences the rate of sodium-proton (Na+-H+)-exchange-dependent swelling of platelets from patients with essential hypertension and normotensive controls. Platelet swelling was detected by measuring the change in optical density of platelet suspensions added to sodium propionate buffer, pH 6.7, at 37 degrees C. We studied 56 subjects, 28 men and 28 women, each group containing 14 normotensive and 14 hypertensive subjects. The groups were well matched for sex, ethnicity and age. That platelet swelling was dependent on Na+-H+ exchange was demonstrated by performing blockade by 5-(N,N-hexamethylene)-amiloride and by measuring its dependence on extracellular Na+ concentration. The rate of swelling of platelets from hypertensive men [(14.2 +/- 0.9) x 10(-3)/s] was higher than that of those from normotensive men [(10.1 +/- 0.5) x 10(-3)/s], normotensive women [(10.0 +/- 0.5) x 10(-3)/s] and hypertensive [(11.1 +/- 0.8) x 10(-3)/s] women. The interaction between sex and hypertension was significant (P < 0.05 by analysis of variance). Sex influences the effect of hypertension on the rate of swelling of platelets exposed to sodium propionate (pH 6.7).

References

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Citations

Jul 15, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·G A SagnellaG A MacGregor
Apr 15, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·S KwiatkowskiD Chlubek

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