Influence of sialic acid groups on the retention of glycosphingolipids in blood plasma.

Biochimica Et Biophysica Acta
A Barkal, J L Di Cesare

Abstract

The removal of several glycosphingolipids from the circulation and their disposal in different tissue and fluid compartments was studied in adult rats. 3H-labeled dihydro analogs of several glycosphingolipids were injected intravenously and radioactivity was measured in arterial blood samples at subsequent time intervals, to obtain half life values for the labeled compound in the plasma. Half life values of less than 1 min were obtained for neutral glycosphingolipids whereas the half lives of labeled gangliosides were much longer and ranged from 3.8 to 21 h. The prompt removal of labeled neutral glycosphingolipids but not of the gangliosides indicates that sialic acid groups play a significant role in the retention of glycosphingolipids in the circulation. The results suggest that neutral glycosphingolipids are rapidly exchanged with their counterparts in a large extraplasma pool and that a major portion of this exchange could occur between plasma and liver. The detection of only a minute fraction of the injected glycosphingolipids in the cerebrospinal fluid indicates that a blood-cerebrospinal fluid barrier exists for these compounds in the rat.

References

Dec 1, 1974·Chemistry and Physics of Lipids·J L Di Cesare, M M Rapport
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Dacremont
Apr 4, 1967·Biochimica Et Biophysica Acta·M M RapportL Graf
Aug 27, 1963·Biochimica Et Biophysica Acta·E SVENNERHOLM, L SVENNERHOLM

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Citations

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T M KloppelD J Morré
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R J DesnickC C Sweeley
Jan 1, 1982·European Journal of Cancer & Clinical Oncology·R KrishnarajR G Kemp
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·S LadischR Seeger

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