Influence of sibutramine on energy expenditure in African American women

Obesity Research
R D StarlingD H Sullivan

Abstract

African American women have a high prevalence of obesity, which partially may be explained by their lower rates of resting energy expenditure (REE). The aim of this study was to examine the influence of acute sibutramine administration on REE and post-exercise energy expenditure in African American women. A total of 15 premenopausal, African American women (age, 29 +/- 5 years; body fat, 38 +/- 7%) completed a randomized, double-blind cross-over design with a 30-mg ingestion of sibutramine or a placebo. Each trial was completed a month apart in the follicular phase and included a 30-minute measurement of REE 2.5 hours after sibutramine or placebo administration. This was followed by 40 minutes of cycling at approximately 70% of peak aerobic capacity and a subsequent 2-hour measurement of post-cycling energy expenditure. There was no difference (p > 0.05) in REE (23.70 +/- 2.81 vs. 23.69 +/- 2.95 kcal/30 min), exercise oxygen consumption (1.22 +/- 0.15 vs. 1.25 +/- 0.15 liter/min), and post-cycling energy expenditure (104.2 +/- 12.7 vs. 104.9 +/- 11.4 kcal/120 min) between the sibutramine and placebo trials, respectively. Cycling heart rate was significantly higher (p = 0.01) during the sibutramine (158 +/- 14 beats/min) vs. pla...Continue Reading

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Citations

Jun 9, 2005·Journal of the American Dietetic Association·Roland N Dickerson, Lori Roth-Yousey
Aug 2, 2008·Expert Opinion on Pharmacotherapy·Bikash Sharma, David C Henderson
Mar 5, 2016·The Cochrane Database of Systematic Reviews·Andrea SiebenhoferThomas Semlitsch
Jun 20, 2006·British Journal of Pharmacology·Angels FisasPetrus Johan Pauwels
Mar 12, 2004·Expert Opinion on Pharmacotherapy·Walker S Carlos Poston, John P Foreyt
Dec 24, 2010·Journal of Hypertension·Jens JordanUNKNOWN Australian and New Zealand Obesity Society
Jan 31, 2008·Annals of Nutrition & Metabolism·Arie RotsteinNachum Vaisman
May 15, 2008·Current Sports Medicine Reports·David G CarfagnoLuke Knowlton
Jan 18, 2021·The Cochrane Database of Systematic Reviews·Andrea SiebenhoferThomas Semlitsch
Apr 29, 2021·Journal of Neuroendocrinology·Teodora GeorgescuLora K Heisler

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