PMID: 11933142Apr 5, 2002Paper

Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin

Phytotherapy Research : PTR
Jitka PsotováJitka Ulrichová

Abstract

Silymarin, an extract of Silybum marianum seeds, and the constituent flavonolignans silybin, silydianin and silychristin, as well as the flavonol quercetin, protected rat heart microsomes and mitochondria against iron-dependent doxorubicin induced lipid peroxidation. Quercetin was found to be more potent than either silymarin or its three constituents, whose cytoprotectivity was comparable. The radical scavenging activity of the compounds was investigated using a DPPH colour reduction assay and cyclic voltametry to assess their antioxidant activities. In contrast to quercetin, silybin, silydianin and silychristin did not chelate iron in aqueous solution. The results suggest that silymarin may prevent doxorubicin-mediated damage to rat heart membrane primarily through a free radical scavenging mechanism.

References

Jan 1, 1989·Free Radical Biology & Medicine·G Powis
Jul 16, 1981·The New England Journal of Medicine·R C YoungC E Myers
Jan 1, 1996·Free Radical Biology & Medicine·S A van AckerA Bast
Feb 19, 1998·The American Journal of Gastroenterology·K FloraK Benner

❮ Previous
Next ❯

Citations

Mar 11, 2006·Cell Biology and Toxicology·K ValentováV Simánek
Jun 8, 2012·Journal of Natural Products·Zhi-You HaoDe-Quan Yu
Dec 17, 2005·Antioxidants & Redox Signaling·Amit K GargBharat B Aggarwal
Apr 23, 2005·The American Journal of Chinese Medicine·Hyun-Ae EumSun-Mee Lee
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimír Kren, Daniela Walterová
Aug 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sílvia CufíJavier A Menendez
Jun 1, 2014·Fitoterapia·A Zholobenko, M Modriansky
Nov 20, 2015·Free Radical Biology & Medicine·Michaela PyszkováJan Vacek
Aug 11, 2007·Journal of Dermatological Science·Alena SvobodováJitka Vostálová
Feb 10, 2007·Journal of Dermatological Science·Alena SvobodováJitka Vostalová
Oct 21, 2009·Journal of Clinical Pharmacology·Roy L HawkeUNKNOWN SyNCH Trial Group
Apr 6, 2005·Reproductive Toxicology·Chidambaram PrahalathanPalaninathan Varalakshmi
Oct 3, 2006·Burns : Journal of the International Society for Burn Injuries·Alena SvobodováJitka Psotová
Apr 14, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sergio Granados-PrincipalM Carmen Ramirez-Tortosa
Sep 23, 2014·European Journal of Pharmacology·Li FanGuangrong Huang
Jun 25, 2016·Nutrition and Cancer·Kamal Razavi-AzarkhiaviGholamreza Karimi
Dec 3, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jan Czepas, Krzysztof Gwoździński
Jun 6, 2007·Integrative Cancer Therapies·Heather GreenleeElena Ladas
Jan 31, 2006·Phytotherapy Research : PTR·G MojzisováJ Mojzis
Dec 14, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hasene Mutlu GençkalFerda Ari
Dec 3, 2016·Molecular Medicine Reports·Kamran HaratiMustafa Becerikli
Mar 16, 2018·Oxidative Medicine and Cellular Longevity·Bassant M BarakatAlaaeldeen M Elbahaie
May 13, 2019·Archives of Dermatological Research·Alena Rajnochová SvobodováJitka Vostálová
Feb 5, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohammad Mehdi OmmatiReza Heidari
Nov 3, 2010·European Journal of Pharmacology·El-Sayed E El-AwadyAsmaa Radwan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.