Influence of single or multiple doses of gentamicin and netilmicin on their cortical, medullary, and papillary distribution.

Antimicrobial Agents and Chemotherapy
M G Bergeron, S Trottier

Abstract

In this study, the comparative intrarenal distribution and accumulation of both gentamicin and netilmicin were investigated in normal rats. The animals received 1, 3, or 14 injections of 10 mg of gentamicin or netilmicin per kg. A total of 324 animals and 648 kidneys were analyzed. These animals were sacrificed at from 1 h to 25 days after the intraperitoneal injections. At each timed interval, the serum, urine, cortex, medulla, and papilla were analyzed for antimicrobial content. The peak serum values of gentamicin (8 to 12 mug/ml) and netilmicin (9 to 14 mug/ml) were close to those found in humans. There was a progressive increase in the cortical concentrations of both antibiotics from a low of 53 mug/g to a high of 719 mug/g when the animals were given increasing doses of the agents. At most timed intervals, the concentrations of gentamicin within the cortex were slightly lower than those of netilmicin. The accumulation of the drugs was also demonstrated in the medulla, where therapeutic levels could be detected for up to 25 days after the cessation of therapy. Even though gentamicin and netilmicin were transiently present in the papilla after 1 or 3 injections, both drugs could still be detected in the papilla on day 25 aft...Continue Reading

References

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Citations

Jun 18, 2002·European Journal of Drug Metabolism and Pharmacokinetics·Aránzazu ZarzueloJosé M Lanao
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T MoriyamaT Kamada
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May 1, 1981·Antimicrobial Agents and Chemotherapy·S Trottier, M G Bergeron
Aug 1, 1985·Antimicrobial Agents and Chemotherapy·M G BergeronP Foucault
May 1, 1988·Antimicrobial Agents and Chemotherapy·P AuclairM G Bergeron
Sep 1, 1988·Antimicrobial Agents and Chemotherapy·M G BergeronP Foucault
Aug 1, 1989·Antimicrobial Agents and Chemotherapy·M G BergeronD Beauchamp
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Oct 1, 1986·Journal of Biomaterials Applications·M SzycherG Battistone
Nov 1, 1987·Antimicrobial Agents and Chemotherapy·M G BergeronD Beauchamp

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