Influence of Slc11a1 on the outcome of Salmonella enterica serovar Enteritidis infection in mice is associated with Th polarization.

Infection and Immunity
Judith CaronDanielle Malo

Abstract

Genetic analyses identified Ses1 as a significant quantitative trait locus influencing the carrier state of 129S6 mice following a sublethal challenge with Salmonella enterica serovar Enteritidis. Previous studies have determined that Slc11a1 was an excellent candidate gene for Ses1. Kinetics of infection in 129S6 mice and Slc11a1-deficient (129S6-Slc11a1(tm1Mcg)) mice demonstrated that the wild-type allele of Slc11a1 contributed to the S. enterica serovar Enteritidis carrier state as early as 7 days postinfection. Gene expression profiling demonstrated that 129S6 mice had a significant up-regulation of proinflammatory genes associated with macrophage activation at day 10 postinfection, followed by a gradual increase in immunoglobulin transcripts, whereas 129S6-Slc11a1(tm1Mcg) mice had higher levels of immunoglobulins earlier in the infection. Quantitative reverse transcription-PCR revealed an increase in Th1 cytokine (Ifng and Il12) and Th1-specific transcription factor Tbx21 expression during infection in both the 129S6 and 129S6-Slc11a1(tm1Mcg) strains. However, the expression of Gata3, a transcription factor involved in Th2 polarization, Cd28, and Il4 was markedly increased in Slc11a1-deficient mice during infection, sugges...Continue Reading

References

Nov 1, 1995·The Journal of Experimental Medicine·S ConstantK Bottomly
Jan 7, 1998·The Journal of Infectious Diseases·L AbelE Schurr
Oct 29, 1998·The American Journal of Physiology·A MouihateQ J Pittman
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·P TamayoT R Golub
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S J McSorleyM K Jenkins
Jul 7, 2000·American Journal of Human Genetics·C M GreenwoodK Morgan
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C P BroerenC H June
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·C S DetweilerS Falkow
May 15, 2001·American Journal of Respiratory Cell and Molecular Biology·J S BurrJ M Green
Jul 19, 2001·The Journal of Biological Chemistry·J M HallK S Korach
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M Liva, R R Voskuhl
Nov 9, 2001·The Journal of Biological Chemistry·Patricia Cuellar-MataSergio Grinstein
Jan 17, 2002·The American Journal of Tropical Medicine and Hygiene·S J MeisnerA V Hill
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gerard J NauRichard A Young
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jennifer C BoldrickDavid A Relman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 11, 2002·Current Molecular Medicine·Pietro Mastroeni
Aug 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael LohoffTak W Mak
Oct 31, 2002·Nature Immunology·Douglas YoungGordon Dougan
Nov 9, 2002·Genes and Immunity·M-F Roy, D Malo
Nov 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michelle L ZaharikB Brett Finlay
Dec 4, 2002·Nature Reviews. Immunology·Kenneth M Murphy, Steven L Reiner
Dec 18, 2002·Genes and Immunity·J FitnessA V S Hill
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanne M LumsdenRichard J Hodes

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Citations

Apr 17, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Marie ChevenonDanielle Malo
May 27, 2011·Genes and Immunity·E RicherD Malo
Nov 26, 2008·Veterinary Parasitology·Stephen K Chapes, Roman R Ganta
Oct 11, 2008·International Journal of Medical Microbiology : IJMM·Prabha BalaramAsma Ismail
Mar 22, 2008·Biochemical and Biophysical Research Communications·Brent NeumannThomas J Gonda
Feb 18, 2012·FEMS Microbiology Reviews·Thomas RubyDenise Monack
Sep 22, 2018·Journal of Molecular Cell Biology·Yong ZhangLigong Chen
May 23, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Eugene KangDanielle Malo
Aug 30, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Nisha SinghRakesh K Singh

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