Influence of sleep states on laryngeal and abdominal muscle response to upper airway occlusion in lambs

Pediatric Research
I Kianicka, J P Praud

Abstract

This study was aimed at describing abdominal and laryngeal muscle responses to upper airway occlusion (UAO) in early life and the effect of sleep states on these responses. Twelve nonsedated, 9-26-d-old lambs were studied. We simultaneously recorded 1) airflow (pneumotachograph + face mask); 2) sleep states (electrocorticogram and electrooculogram); 3) abdominal muscle (external obliquus) electromyogram (EMG); and 4) glottic constrictor (thyroarytenoid) and dilator (posterior cricoarytenoid and cricothyroid) muscle EMGs. The pneumotachograph was repeatedly occluded for 15-30 s in wakefulness and natural sleep. We analyzed 90 occlusions during wakefulness (11 lambs), 28 during non-rapid eye movement (nREM) sleep (six lambs), and 23 during rapid eye movement (REM) sleep (five lambs). A phasic expiratory external obliquus EMG was present during baseline and progressively increased throughout UAO in wakefulness and nREM sleep, but not in REM sleep. Phasic thyroarytenoid EMG progressively increased during inspiratory efforts throughout UAO in wakefulness and nREM sleep, paralleling the increase in glottic dilator (posterior cricoarytenoid and cricothyroid) EMG. In contrast, glottic muscle response to UAO in REM sleep was severely bl...Continue Reading

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Citations

Mar 28, 2003·Respiratory Physiology & Neurobiology·Philippe ReixJean-Paul Praud
Dec 13, 2006·BMJ : British Medical Journal·Shirley L TonkinAlistair Jan Gunn
Nov 1, 2002·Pediatric Research·Patrick LétourneauJean-Paul Praud
Feb 20, 2013·Respiratory Physiology & Neurobiology·Jacopo P Mortola, Peter B Frappell
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dennis McGintyRon Szymusiak
Jun 8, 2004·Journal of Applied Physiology·Philippe ReixJean-Paul Praud
Mar 3, 2007·Journal of Applied Physiology·François Moreau-BussièreJean-Paul Praud

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