Influence of smoking on long-term clinical results of intrabony defects treated with regenerative therapy

Journal of Periodontology
P S RosenM A Reynolds

Abstract

This retrospective study compares the short-term (1 year) and long-term (2 to 5 year) clinical results of regenerative therapy in clinical private practice using a bone allograft for the treatment of intrabony defects in smokers and non-smokers. A total of 110 intrabony lesions were treated with demineralized freeze-dried bone allograft (DFDBA) following thorough defect debridement and root preparation in 53 patients (15 cigarette smokers and 38 non-smokers). Assessments of clinical attachment level (CAL) and probing depth (PD) were recorded at pre-treatment, 1 year post-treatment, and 2 to 5 years post-treatment. At 1 year post-treatment, significant gains in mean CAL were maintained for both smokers (2.7 mm) and non-smokers (3.4 mm). Similarly, significant reductions in mean PD were observed for smokers (3.0 mm) and non-smokers (3.8 mm) at the 1-year follow-up. However, when comparing relative improvements in clinical measures, smokers were found to exhibit significantly poorer treatment results (i.e., sites exhibited less CAL gain) at 1 year and 2 to 5 years follow-up. Relative to pre-treatment scores, differences in improvements observed for CAL at the 1-year evaluation (29.2% for smokers and 42.5% for non-smokers) were sus...Continue Reading

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Citations

Feb 24, 2001·Advances in Therapy·P Obeid, P Bercy
Jun 13, 2002·Journal of Clinical Periodontology·Leonardo TrombelliGiovanni Zucchelli
Oct 23, 2002·Journal of Clinical Periodontology·Ahmed Y Gamal, Mohammed M Bayomy
Jul 13, 2012·The Journal of Oral Implantology·Paul A SchnitmanMaria Dona
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Mar 24, 2006·Journal of Clinical Periodontology·L HeasmanP A Heasman
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