PMID: 696414Jan 1, 1978Paper

Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure, serum electrolytes, renin and aldosterone in essential hypertension

Acta Medica Scandinavica
P van BrummelenJ de Graeff

Abstract

To determine the influence of dietary sodium intake on the effects of hydrochlorothiazide (HCT) on blood pressure (BP), serum electrolytes, renin and aldosterone, nine male patients with uncomplicated essential hypertension were studied during the following therapeutic regimes: 1) sodium restriction alone (50 mmol/day), 2) sodium restriction combined with HCT (50 MG TWICE DAILY), 3) HCT alone, and 4) sodium restriction combined with HCT. Low sodium diet alone and HCT alone lowered BP to the same extent. The combination of HCT and sodium restriction had no extra effect on supine BP, but elicited complaints of dizziness and weakness in each patient, and overt orthostatic hypotension in three cases. Sodium restriction during HCT treatment caused hyponatraemia and aggravated hypokalaemia. Hyponatraemia could not be accounted for solely by changes in cumulative sodium balance. Plasma renin concentration rose markedly during the combined treatment. Plasma aldosterone was normal during HCT alone, but elevated when HCT was combined with sodium restriction. These results cast some doubt on the therapeutic value of prescribing a low sodium diet to patients with essential hypertension treated with thiazide diuretics. Overactivity of the r...Continue Reading

References

Mar 15, 1975·The Medical Journal of Australia·P Kincaid-SmithP Fang
Jan 22, 1977·British Medical Journal·C J RobertsA J Donley
Dec 2, 1976·The New England Journal of Medicine·H GavrasH R Brunner
Jun 10, 1976·The American Journal of Medicine·D H StreetenT H Dalakos
Jun 1, 1976·Endocrinology·G H WilliamsL M Braley
May 1, 1973·The American Journal of Cardiology·H P DustanR C Tarazi
Aug 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·M FrölichA J Moolenaar
Dec 1, 1971·Annals of Internal Medicine·M P FichmanN Telfer
Jan 1, 1967·Annual Review of Pharmacology·L Tobian
Jul 1, 1970·The Journal of Clinical Endocrinology and Metabolism·F BayardC J Migeon
Oct 1, 1966·The Australian Journal of Experimental Biology and Medical Science·J R Blair-WestR D Wright
May 1, 1954·The Journal of Clinical Investigation·J H LARAGH
Jun 1, 1959·The American Journal of Medicine·H O HEINEMANNJ H LARAGH
Oct 11, 1960·Annals of the New York Academy of Sciences·W HOLLANDERR W WILKINS
Oct 11, 1960·Annals of the New York Academy of Sciences·P J TALSO, A J CARBALLO
Feb 1, 1961·Circulation·B M WINER
Aug 1, 1960·The Journal of Clinical Investigation·W Y AU, L G RAISZ
May 1, 1963·The Journal of Clinical Investigation·J O DAVISJ T HIGGINS
Aug 16, 1962·The New England Journal of Medicine·O D JOHNSONR V FORD

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Citations

Sep 1, 1986·The Proceedings of the Nutrition Society·P M DodsonS P Waldron
May 1, 1992·Clinical and Experimental Pharmacology & Physiology·T C BeardT Dwyer
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·P Hjemdahl
May 7, 2016·Journal of the American Society of Nephrology : JASN·Anne SinningRégine Chambrey
Jul 9, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Masafumi NakayamaYoshifusa Aizawa
May 16, 2015·Journal of the American Society of Nephrology : JASN·Aruna R NatarajanPedro A Jose
Jul 6, 1987·The Medical Journal of Australia·T C Beard, R F Heller
Jul 6, 1987·The Medical Journal of Australia·T C Beard, I Farrance
Nov 1, 2007·Journal of the American Society of Hypertension : JASH·Biff F Palmer, Amir Said Alizadeh Naderi

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