Influence of sodium lauryl sulphate on 2,4-dinitrochlorobenzene-induced lymph node activation

Toxicology
M CumberbatchI Kimber

Abstract

The influence of the anionic surfactant sodium lauryl sulphate (SLS) on the ability of the contact allergen 2,4-dinitrochlorobenzene (DNCB) to provoke draining lymph node cell proliferative responses, a correlate of skin sensitizing potential, has been examined in mice. Topical application of 10% SLS with 0.1% DNCB caused a more vigorous proliferative response than did exposure to 0.1% DNCB alone. Lower concentrations (0.1% or 1%) of SLS were ineffective and 10% SLS failed to influence proliferative responses to higher concentrations (0.5% or 1%) of DNCB. Using an in vitro model for measurement of percutaneous absorption 10% SLS was shown not to increase the skin penetration of 0.1% DNCB. We therefore examined the influence of SLS on the accumulation of dendritic cells (DC) in lymph nodes draining the site of exposure, an important early event during the induction phase of skin sensitization. The frequency of DC in draining nodes was measured following topical application of SLS, DNCB or a combination of both. Epicutaneous exposure to 0.1% DNCB caused only a modest increase in the number of lymph node DC. However, 10% SLS or a mixture of 10% SLS with 0.1% DNCB each resulted in a significant elevation of DC numbers. It is propos...Continue Reading

References

Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Kimber, D A Basketter
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Feb 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Kimber, R J Dearman
Jan 1, 1989·International Archives of Allergy and Applied Immunology·A KinnairdI Kimber
Jan 1, 1970·International Archives of Allergy and Applied Immunology·L G Wiest, E G Jung
Jan 1, 1984·International Archives of Allergy and Applied Immunology·K MillerM Malkovský
Aug 1, 1986·International Journal of Cosmetic Science·R C ScottP H Dugard

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Citations

Oct 8, 1999·Journal of Applied Toxicology : JAT·R J DearmanI Kimber
Jun 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D A BasketterI Kimber
Sep 22, 1994·Toxicology·I KimberD A Basketter
Oct 19, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K ClausenG D Nielsen
Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I KimberH-W Vohr
Oct 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D A BasketterS E Loveless
Jun 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Aug 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I KimberD A Basketter
Mar 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C A RyanG F Gerberick
Jan 23, 1999·Current Opinion in Immunology·I KimberR J Huby
Apr 4, 1998·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·J HiltonI Kimber
May 30, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ian Kimber, Rebecca J Dearman
Apr 9, 2002·Australian Family Physician·Mary Christoforou
Sep 1, 1999·The British Journal of Dermatology·M CumberbatchI Kimber
Mar 29, 2000·The British Journal of Dermatology·I KimberC E Griffiths
Nov 13, 2001·The British Journal of Dermatology·J English
Feb 14, 2002·The British Journal of Dermatology·M BhushanC E M Griffiths
Sep 30, 2000·Clinical and Experimental Dermatology·M CumberbatchI Kimber
Apr 16, 2002·Clinical and Experimental Dermatology·Harvey R SmithJ P McFadden
Oct 1, 1995·Journal of Toxicology and Environmental Health·T R AutonI Kimber
Nov 15, 2005·Contact Dermatitis·Holger LessmannWolfgang Uter
May 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M KrastevaD Schmitt
Jul 13, 2011·Journal of Allergy·Stacey E AndersonB J Meade
Apr 28, 2004·BMC Immunology·Yanina EberhardHoracio Marcelo Serra
Feb 13, 2003·Contact Dermatitis·Ian KimberG F Gerberick
Feb 16, 2002·Contact Dermatitis·G F GerberickD A Basketter
Jul 7, 2014·Cellular and Molecular Life Sciences : CMLS·Stefan F Martin
Dec 2, 2015·Regulatory Toxicology and Pharmacology : RTP·David Basketter, Bob Safford
Jul 22, 2008·Regulatory Toxicology and Pharmacology : RTP·Pauline M McNameeMichael K Robinson
Nov 18, 2003·Clinical and Experimental Immunology·F Dieli
Oct 17, 2008·European Journal of Immunology·Krista OuwehandSusan Gibbs
May 3, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·U JappeW Uter
Aug 19, 2007·Journal of Applied Toxicology : JAT·David W Roberts, Aynur O Aptula
Jan 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J P McFaddenI Kimber
Sep 13, 2005·Cytokine·C E M GriffithsI Kimber
Sep 8, 2012·Journal of Immunotoxicology·Joseph S AinscoughIan Kimber
Sep 8, 2012·Journal of Immunotoxicology·Ian Kimber, Raymond Pieters
Sep 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Marie CumberbatchIan Kimber

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