PMID: 3298184Apr 1, 1987

Influence of specific growth rate and nutrient limitation upon the sensitivity of Escherichia coli towards chlorhexidine diacetate

The Journal of Applied Bacteriology
N E Wright, P Gilbert

Abstract

The sensitivity of Escherichia coli to chlorhexidine has been assessed for cells grown in a chemostat at a variety of specific growth rates, under conditions of carbon, nitrogen, phosphorus and magnesium limitation. At slow rates of growth (ca 0.08/h) little difference in sensitivity was observed. As growth rate was increased, however, the sensitivity of nitrogen- and carbon-limited cells increased whilst that of magnesium- and phosphate-limited cells decreased. It was not possible to correlate the observed patterns of chlorhexidine sensitivity with any single measure of cell envelope composition (phospholipid content, lipopolysaccharide, envelope proteins, etc.). The results presented are not consistent, therefore, with any simple model for chlorhexidine binding or action and more probably reflect subtle interaction between chlorhexidine, phospholipid-lipopolysaccharide complexes and cations within the envelope.

References

Jan 1, 1992·The Journal of Applied Bacteriology·B H PyleG A McFeters
Sep 3, 1999·Journal of Clinical Pharmacology·M Habash, G Reid
May 1, 2010·Journal of Cellular Physiology·Jun WuJianping Xie
Sep 24, 2009·Proteome Science·Svenja LüdersEzequiel Franco-Lara
Feb 9, 2000·Letters in Applied Microbiology·D L Greenway, R R England
Sep 16, 2005·Journal of Applied Microbiology·P Gilbert, L E Moore
Jan 1, 1993·The Journal of Applied Bacteriology·M R Brown, P Gilbert
Aug 28, 2019·Nature Microbiology·Allison J LopatkinJames J Collins

Citations

Jan 14, 1975·Biochimica Et Biophysica Acta·M ImaiS Nojima
Jan 1, 1979·Advances in Microbial Physiology·H Nikaido, T Nakae
Oct 1, 1976·Journal of Bacteriology·G M Decad, H Nikaido
May 1, 1977·The Journal of Antimicrobial Chemotherapy·M R Brown
Dec 1, 1969·Journal of General Microbiology·M R Brown, J Melling
Jan 1, 1973·Journal of Pharmaceutical Sciences·C Hansch, J M Clayton
May 1, 1974·Biochemical Pharmacology·J G Elferink, H L Booij
Sep 1, 1969·Biotechnology and Bioengineering·D W Tempest, D C Ellwood
Feb 28, 1980·Biochimica Et Biophysica Acta·E M El Mashak, J F Tocanne
Aug 1, 1984·The Journal of Applied Bacteriology·P BroxtonP Gilbert
Jan 11, 1984·Biochimica Et Biophysica Acta·T IkedaR A Hann
Feb 1, 1982·The Journal of Applied Bacteriology·M T Nadir, P Gilbert
Oct 1, 1981·Antimicrobial Agents and Chemotherapy·K J HarderM Matsuhashi
Aug 1, 1980·The Journal of Applied Bacteriology·M M Al-Hiti, P Gilbert

Related Concepts

Alkalescens-Dispar Group
Magnesium Measurement
Complex (molecular entity)
Outer Membrane Lipoproteins, Bacterial
Phosphate Measurement
Chlorhexidine
Phosphorus Measurement
Cations
Phospholipids
Chlorhexidine diacetate

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