PMID: 9179607Mar 1, 1997Paper

Influence of stage classification, tumor differentiation and mode of invasion against clinical and histopathological effects on low dose sequential methotrexate and 5-fluorouracil administration as neo-adjuvant chemotherapy for oral squamous cell carcinoma

In Vivo
J Asaumi

Abstract

We report on the influences of stage classification, tumor differentiation and mode of invasion against clinical and histopathological effects associated with low dose sequential methotrexate (MTX) and 5-fluorouracil (5-FU) (MF therapy) as neo-adjuvant chemotherapy in oral cancer. The oral cancer of 22 patients was treated as follows: MTX (75 mg/body) was administrated by intravenous infusion for 1 hour, followed by 5-FU (500 mg/body) intravenous infusion for 2 hours on Day 1, MTX (75 mg/body) intravenous infusion for 1 hour on Day 4, and parenteral dose of leucovorin on Day 2 and Day 5. The MF therapy of 1-5 courses was performed weekly or every 2 weeks. The clinical response rate was lower in stage IV than in the other stages. There was no difference in the rate of tumor differentiation by WHO grade classification, I and II. The rate was higher in grade 1, 2 and 3 than in grade 4C and 4D due to mode of invasion. The histological response rate was higher in stage I and II than in stage III and IV. The response rate was higher in grade II than in grade I, but was higher in grade 1 and 2 than in grade 3 and 4C. However, the response rate in grade 4D was good (66.7%; 2/3). Histological response was demonstrated only in partial or...Continue Reading

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