PMID: 11340140May 8, 2001Paper

Influence of stent edge angle on endothelialization in an in vitro model

Journal of Vascular and Interventional Radiology : JVIR
M HamuroJ Luo

Abstract

To investigate the influence of topographic features in the path of migrating endothelial cells, specifically the effect of edge angle of intravascular metallic material on endothelialization. Flat 1-cm x 1-cm 316-L pieces of stainless steel were placed on confluent monolayers of human aortic endothelial cells. The thickness of each metal piece was ground to achieve an edge angle of 35 degrees, 70 degrees, 90 degrees, or 140 degrees (n = 6 each) in relation to the endothelial surface. Migration distance and density of endothelial cell coverage on the metal pieces were measured in groups of six each under static conditions at 4, 7, and 11 days and flow conditions (16 dynes/cm(2)) at 4 days. Endothelial cell migration distance along the surface of the pieces with edge angles of 35 degrees was significantly greater than that with those with larger angles (P < .05) under static and flow conditions. The migration distances on the 35 degrees piece were 87.5%, 47.3%, 57.1%, and 66.1% greater than those on the 90 degrees piece at the upstream, downstream, right, and left edges, respectively. There were no significant differences in cell density among different angle groups under flow or static conditions. The edge angle of intravascula...Continue Reading

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Citations

May 28, 2009·Annals of Biomedical Engineering·Juan M Jiménez, Peter F Davies
May 26, 2009·Journal of Materials Science. Materials in Medicine·Animesh ChoubeyEugene A Sprague
Jul 18, 2012·Tissue Engineering. Part B, Reviews·Michael C GibbonsKristen O'Halloran Cardinal
Dec 14, 2005·Journal of Biomedical Materials Research. Part a·Hung-I YehCheng-Ho Tsai
Jul 1, 2009·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·James E Moore
Mar 7, 2007·Expert Review of Cardiovascular Therapy·Matteus A M LinsenWillem Wisselink
Oct 4, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Miki HirabayashiBastien Chopard
Dec 24, 2004·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·M OhtaD A Rüfenacht
Aug 19, 2021·Journal of the Royal Society, Interface·Duy T NguyenJuan M Jiménez

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