Influence of streptozotocin-induced diabetes in rats on the lithium content of tissue and the effect of dietary lithium supplements on this diabetic condition

Metabolism: Clinical and Experimental
M HuH Wu

Abstract

To study the effects of lithium supplementation on the diabetic condition, we measured the lithium concentration in the liver, kidney, and muscle from streptozotocin (STZ)-induced diabetic male Sprague-Dawley (SD) rats that were either treated or untreated with peroral lithium carbonate (0.3 mg/mL). The data showed that the lithium content of the liver and muscle was significantly lower in STZ rats than in normal control rats (0.22 +/- 0.05 v 1.30 +/- 0.15, P < .01, and 0.79 +/- 0.30 v 2.48 +/- 2.00 microg/g, respectively). After 4 weeks of lithium carbonate supplementation, we found that (1) the lithium content of the liver and muscle returned to the normal range, (2) the extent of STZ-mediated destruction of beta cells in the pancreas decreased, (3) fasting blood glucose (FBG) and 2-hour postprandial blood glucose (PBG) decreased (P < .05), (4) among the indicators of oxidative stress and antioxidant defenses, blood lipid peroxidate (LPO) decreased and erythrocyte superoxide dismutase (RBC-SOD) and glutathione (GSH) returned to normal, and (5) hepatic LPO decreased and glutathione peroxidase (GSH-Px) increased. These results suggest that the restoration of lithium to control levels in the liver and muscle of diabetic animals ...Continue Reading

References

Apr 21, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Małgorzata KiełczykowskaKazimierz Pasternak
Jul 29, 2008·Pulmonary Pharmacology & Therapeutics·Masaki FujitaYoichi Nakanishi
Jul 11, 2017·Journal of the Chinese Medical Association : JCMA·Kyung-A HwangJin Song

Citations

Oct 1, 1978·Endocrinology·E R ArquillaS Miyamoto
Sep 1, 1990·Diabetologia·G PaolissoP Lefèbvre
Mar 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Z R ShiY S Kim
Oct 1, 1987·The Journal of Clinical Investigation·L RossettiR A DeFronzo
Nov 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·M L Failla, C Y Gardell
Sep 1, 1994·Biological Chemistry Hoppe-Seyler·B HellerH Kolb
Jan 1, 1994·Medical Hypotheses·J E Sprietsma, G E Schuitemaker
Mar 1, 1996·Diabetologia·G Paolisso, D Giugliano
Dec 24, 1997·Biological Trace Element Research·M HuC Chao
Mar 1, 1981·Biological Trace Element Research·H P Roth, M Kirchgessner

Related Concepts

Fasting Blood Glucose Measurement
Lithium Measurement
Antioxidants
Benign Tumor of Pancreas
SD, Rat Strain
Myopathy
Hepatic
Oxidative Stress
Oxidative Stress Analysis
Glutathione Measurement

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