PMID: 8958151Jan 1, 1997Paper

Influence of structure on the antioxidant activity of indolinic nitroxide radicals

Free Radical Biology & Medicine
J AntosiewiczLucedio Greci

Abstract

An in vitro study was carried out to verify whether the chain length of a substituent on an indolinic nitroxide could influence its antioxidant activity in different biological environments subjected to oxidative stress. Three distinct indolinic nitroxides were synthesized and compared with vitamin E and Trolox (a hydrophilic analogue of vitamin E), where the only difference between the nitroxides was the length of the hydrocarbon chain in the 2-position of indole, namely 2 (C2), 10 (C10), and 18 (C18) carbons. All the nitroxides were effective in preventing oxidation of bovine serum albumin, but to different extents, with the longer chain derivatives being more efficient. However, the C2 compound was the most efficient in preventing lipid peroxidation in microsomal membranes. The C2 and C18 compounds, Trolox, and vitamin E protected microsomal protein oxidation to the same extent at the highest concentration used (13 microM). The nitroxide with a C10 chain was less effective in this system. The influence of these compounds on the enzymatic activity of two mitochondrial proteins subjected to oxidative stress was also studied by means of oxygraph measurements. Mitochondrial rotenone-sensitive NADH oxidase and succinate oxidase r...Continue Reading

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Citations

Feb 17, 2001·Journal of Applied Toxicology : JAT·A M Sciuto, T S Moran
Aug 23, 2001·Pharmacology & Therapeutics·A Bomzon, P Ljubuncic
Jul 13, 2000·Free Radical Biology & Medicine·E DamianiL Greci
Mar 4, 2000·Free Radical Biology & Medicine·E DamianiP Hrelia
Jan 5, 2002·Bioorganic & Medicinal Chemistry Letters·Hong-Yu Zhang, Lan-Fen Wang
Oct 25, 2002·Redox Report : Communications in Free Radical Research·L RackovaM Majekova
May 9, 2003·Biological & Pharmaceutical Bulletin·Süreyya Olgen, Tülay Coban
Sep 11, 2004·Bioorganic & Medicinal Chemistry·Lucia RackováMilan Stefek
Jul 2, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rosita GabbianelliElisabetta Damiani
Dec 8, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Süreyya ÖlgenSerpil Nebioğlu
Aug 7, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·Pinar BozkayaDogu Nebioglu
Jun 24, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Süreyya OlgenDoğu Nebioğlu
Apr 6, 2004·Free Radical Research·Elisabetta DamianiLucedio Greci
Mar 25, 2005·Free Radical Research·Elisabetta DamianiLucedio Greci
Sep 13, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·Süreyya OlgenTulay Coban
Feb 23, 2007·Archiv der Pharmazie·Süreyya OlgenTülay Coban

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