Influence of substitutive ovarian steroids in the nuclear and cell body volumes of neurons in the posterodorsal medial amygdala of adult ovariectomized female rats

Neuroscience Letters
Juliana de CastilhosMatilde Achaval

Abstract

The volumes of the neuronal nucleus and the cell body in the left posterodorsal medial amygdala (MePD) of adult ovariectomized (OVX) female rats submitted to different hormonal therapies were studied here, aiming to reveal possible influence of substitutive sex steroids in these morphological parameters. One week following ovariectomy and at the end of treatments, brains were cut to semi-thin sections (1 microm) and stained with 1% toluidine blue for stereological estimations, carried out using the Cavalieri method and the technique of point counting. Both the volume of the neuronal nucleus and the soma showed a statistically significant difference when comparing the data among OVX females treated with vehicle (V), estradiol (EB) alone, EB plus progesterone (EB+P) or P alone [n=5 rats in each group; one-way ANOVA test, P<0.01 in both cases]. The Tukey test showed that OVX and EB+P treated females had higher mean neuronal nucleus and somatic volumes when compared to V (P<0.01) or EB alone (P<0.01). Also, OVX females treated with P alone showed larger mean neuronal nucleus and somatic volumes when compared to V (P<0.05). These results suggest that the neuronal nucleus and the somatic volumes can be modulated by substitutive ovari...Continue Reading

References

Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Dec 5, 1997·The Journal of Comparative Neurology·P J ShughrueI Merchenthaler
Apr 4, 1998·Brain Research. Molecular Brain Research·M OsterlundY L Hurd
Dec 26, 2001·Brain Research. Brain Research Reviews·G D PetrovichL W Swanson
Feb 15, 2003·Cellular and Molecular Neurobiology·Hugo F Carrer, María J Cambiasso
May 2, 2003·Annals of the New York Academy of Sciences·George F Alheid
Jun 6, 2003·Hormones and Behavior·Béatrice GrécoJeffrey D Blaustein
Feb 24, 2004·Annual Review of Physiology·Adriana MaggiElisabetta Vegeto
Dec 18, 2007·Frontiers in Neuroendocrinology·Nandini Vasudevan, Donald W Pfaff
Oct 15, 2008·The Journal of Comparative Neurology·Ryan T JohnsonCynthia L Jordan
May 27, 2009·The Journal of Steroid Biochemistry and Molecular Biology·América Vanoye-CarloMarco Cerbón

❮ Previous
Next ❯

Citations

Nov 8, 2011·Behavioural Brain Research·Nobuo IzumoTakayuki Manabe
Sep 8, 2015·The Journal of Pain : Official Journal of the American Pain Society·Arjun KumarAlan R Gintzler
Dec 14, 2011·Human Brain Mapping·Lindsey OssewaardeGuillén Fernández
Apr 9, 2015·Frontiers in Neuroscience·Kazuya TomiharaSaki Matsumoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.