Influence of superoxide radical and hydrogen peroxide on arachidonic acid mobilization

Archives of Biochemistry and Biophysics
J Martínez, Juan José Moreno

Abstract

Murine resident peritoneal macrophages can produce potent reactive oxygen species (ROS) and arachidonic acid metabolites such as eicosanoids, which have important roles in host defense and the pathogenesis of inflammation. Phagocytosis and macrophage activation are believed to enhance secretion of ROS and eicosanoids. Therefore, we investigated the influence of ROS release on arachidonate mobilization. Our results shown that ROS could be involved in the pathways that result in [3H]AA release. We suggested that phosphorylation and dephosphorylation processes stimulated by ROS could increase arachidonic acid mobilization via a PKC-independent pathway.

Citations

Nov 28, 2002·Alimentary Pharmacology & Therapeutics·L Kruidenier, H W Verspaget
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·A A FryerM A Spiteri
Oct 2, 2002·Journal of Neurochemistry·Mauro MaccarroneAlessandro Finazzi-Agrò
Nov 17, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y-L LeeY L Guo
Jul 16, 2003·Allergy·A HeinzmannK A Deichmann
Jul 24, 2007·International Archives of Allergy and Immunology·Fumiaki KamadaYoichi Suzuki
Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta MuszyńskaElżbieta Skrzydlewska
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A BananA Keshavarzian
Jan 13, 2006·Critical Reviews in Food Science and Nutrition·Eunok Choe, David B Min
Aug 8, 2001·Archives of Biochemistry and Biophysics·J Martínez, J J Moreno
May 29, 2002·Thrombosis Research·Tze-Wen ChungShu-Hsun Chu

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