Influence of surgery on serum concentrations of hyaluronan

Critical Care Medicine
S BergT C Laurent

Abstract

To investigate the changes in serum hyaluronan concentrations in response to surgery. A prospective case series evaluating serum hyaluronan concentrations before, during, and after surgery. Operating room and recovery room of a university hospital. Twelve consecutive patients undergoing vascular surgery because of arterial insufficiency of the lower extremities. Serum hyaluronan concentrations were measured before and after induction of anesthesia and before, during, and after surgery. Routine chemical analyses of blood samples were made before and after surgery. Blood loss and fluid volumes infused were registered. Mean serum hyaluronan concentrations increased from baseline 25 +/- 10 (SD) to 36 +/- 15 micrograms/L (p < .05) during surgery, and increased further at 1 hr after the end of surgery to 52 +/- 38 micrograms/L (p < .001 compared with baseline), but had decreased nearly to baseline levels at 2 hrs postoperatively. A positive correlation was seen between peak hyaluronan concentrations and baseline serum hyaluronan levels (r2 = .73; p < .001), but no strong relationship was seen between serum hyaluronan concentrations and other parameters studied. Surgery is accompanied by a small increase in serum hyaluronan concentrat...Continue Reading

Citations

Feb 15, 1997·The Journal of Surgical Research·P WangI H Chaudry
Jun 1, 1996·Annals of Medicine·T C LaurentJ R Fraser
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Lin YiWen-Fu Tang

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