Influence of surgery on the responsiveness of blood lymphocytes in patients with advanced cancer

Journal of Surgical Oncology
I GrzelakA Engeset

Abstract

The effect of surgery on peripheral blood mononuclear cell responsiveness to mitogens and suppressor cell (SC) activity assessed in a concanavalin A (ConA) assay were studied in patients with stage 0 and stage III-IV cancer. Patients were exposed to a similar surgical trauma the same type of anaesthesia, and to no pre- and early postoperative radio- or chemotherapy. A more pronounced postoperative decrease in the lymphocyte count, responsiveness to phytohemagglutinin (PHA) and ConA, and in the SC activity was found in the nonadvanced than advanced cancer group. These findings point to an impaired mobilization and distribution capacity of circulating lymphocytes in patients with advanced neoplastic disease.

References

Feb 1, 1979·The Journal of Clinical Investigation·C L Miller, C C Baker
Apr 1, 1979·The Surgical Clinics of North America·R J Howard
Mar 1, 1977·The Journal of Surgical Research·J L TarpleyP B Chretien
Sep 1, 1976·The Journal of Surgical Research·G C MillerR V Pierre
Dec 1, 1970·Annals of Internal Medicine·O Barrett
Jan 1, 1984·Cancer Immunology, Immunotherapy : CII·Y HayashiM Sato
Jan 1, 1984·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·I GrzelakA Engeset
Apr 1, 1981·The British Journal of Surgery·N W EversonP R Bell

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Citations

Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo

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