Influence of Surgical Resection of Hepatic Metastases From Gastric Adenocarcinoma on Long-term Survival: Systematic Review and Pooled Analysis

Annals of Surgery
Sheraz R MarkarGeorge B Hanna

Abstract

The objectives of this systematic review and pooled analysis were to examine long-term survival, morbidity, and mortality following surgical resection of gastric cancer hepatic metastases and to identify prognostic factors that improve survival. Patients with hepatic metastases from gastric cancer are traditionally treated with palliative chemotherapy. A systematic literature search was undertaken (1990 to 2015). Publications were included if they studied more than 10 patients undergoing hepatectomy for hepatic metastasis from gastric adenocarcinoma in the absence of peritoneal disease or other distant organ involvement. The primary outcome was the hazard ratio (HR) for overall survival. The influence of liver metastasis related factors; multiple vs single and metachronous vs synchronous upon survival was also assessed. The median number of resections for the 39 studies included was 21 (range 10 to 64). Procedures were associated with a median 30-day morbidity of 24% (0% to 47%) and mortality of 0% (0% to 30%). The median 1-year, 3-year, and 5-year survival were 68%, 31%, and 27%, respectively. Survival was improved in Far Eastern compared with Western studies; 1-year (73% vs 59%), 3-year (34% vs 24.5%), and 5-year (27.3% vs 16...Continue Reading

References

Mar 23, 1991·JAMA : the Journal of the American Medical Association·W J BlotJ F Fraumeni
Aug 1, 1994·The British Journal of Surgery·T OchiaiK Maruyama
May 30, 2001·American Journal of Surgery·S AmbiruN Nakajima
Dec 26, 2001·Annals of Surgery·Keiichi OkanoHajime Maeta
Oct 26, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Johannes ZacherlFriedrich Längle
Oct 20, 2004·Annals of Surgery·Michael D'AngelicaMartin S Karpeh
Nov 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D NittiUNKNOWN ICCG
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Nov 24, 2006·Annals of Surgery·René AdamDenis Castaing
Jan 16, 2007·Journal of Surgical Oncology·Yoshihiro SakamotoMitsuru Sasako
Oct 12, 2007·Japanese Journal of Clinical Oncology·Rintaro KogaToshiharu Yamaguchi
Feb 29, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S H CheonH C Chung
Mar 11, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A ThelenP Neuhaus
Aug 2, 2008·The New England Journal of Medicine·Mitsuru SasakoUNKNOWN Japan Clinical Oncology Group
Jan 28, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G A M TiberioS M Giulini
Apr 11, 2009·Journal of Hepato-biliary-pancreatic Surgery·Takashi NomuraWataru Kimura
Oct 20, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K AveryJ Blazeby
Mar 23, 2010·Hepatology International·Hironori TsujimotoKazuo Hase
Sep 6, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yves DittmarUtz Settmacher
Feb 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Mattia GaranciniFabrizio Romano
Feb 23, 2012·World Journal of Surgery·Claus W SchildbergA Perrakis
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Apr 13, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-L QiuY-F Yuan
Apr 20, 2013·World Journal of Gastroenterology : WJG·Lei ChenYu-Xin Chen
Jun 15, 2013·Annals of Surgical Oncology·Benjamin SchmidtSam S Yoon
Jul 12, 2013·Journal of Gastric Cancer·Hyoung-Un BaekChang-Sup Lim
Sep 4, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yukinori KurokawaHaruhiko Fukuda
May 23, 2014·Journal of Surgical Oncology·James P De Andrade, James J Mezhir
Sep 6, 2014·Annals of Surgical Oncology·Guido Alberto Massimo TiberioGiovanni de Manzoni
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Mar 5, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sheraz R MarkarGeorge B Hanna
Nov 1, 2016·Expert Review of Anticancer Therapy·Gonzalo Tapia RicoTimothy J Price
Feb 15, 2017·BMC Surgery·Ying-Yang LiaoLe-Qun Li
Nov 4, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·T Schmidt, S P Mönig
Jun 20, 2018·Asia-Pacific Journal of Clinical Oncology·Hwee Leong TanMelissa Ching Ching Teo
May 19, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S Beckert, A Königsrainer
Oct 13, 2018·Journal of Hepato-biliary-pancreatic Sciences·Keiji SanoUNKNOWN Japanese Society of Hepato-Biliary-Pancreatic Surgery
May 4, 2018·Oncotarget·Magdalena CisłoWojciech Piotr Polkowski
Sep 24, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Keiichi FujiyaKen Yamaguchi
May 31, 2018·Updates in Surgery·Silvia MinistriniGuido A M Tiberio
Jun 8, 2018·European Surgery : ACA : Acta Chirurgica Austriaca·Christoph SchwarzMartin Bodingbauer
Nov 30, 2018·World Journal of Gastrointestinal Oncology·Tommaso ZurleniStefano Rausei
Feb 7, 2020·International Journal of Molecular Sciences·Jin-On JungThomas Schmidt
Feb 6, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kozo KataokaUNKNOWN EORTC GITCG Group and JCOG SCGC Group
Mar 24, 2017·Innovative Surgical Sciences·Stefan Heinrich, Hauke Lang
Jan 11, 2020·Frontiers in Oncology·Zai LuoChen Huang
Sep 10, 2020·Cancer Management and Research·Pengfei YuXiangdong Cheng
Mar 7, 2017·World Journal of Hepatology·Nobuyuki Takemura, Akio Saiura
Jan 1, 2020·BMC Cancer·Alexander I DamanakisFelix Popp
Mar 5, 2020·Therapeutic Advances in Medical Oncology·Kecheng Zhang, Lin Chen
Jul 16, 2020·Interactive Cardiovascular and Thoracic Surgery·Dimitrios SchizasTheodoros Liakakos
Sep 17, 2020·Cancers·Alessandro ParisiCorrado Ficorella
Jun 21, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M F J SeesingUNKNOWN Gastroesophageal Metastasectomy Group
Sep 13, 2020·International Journal of Surgery Case Reports·Flavio Roberto TakedaIvan Cecconello
Apr 25, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Eliza HagensSheraz R Markar
Nov 23, 2018·The Journal of Surgical Research·Omar PicadoDanny Yakoub
Jul 6, 2021·International Cancer Conference Journal·Chihiro MatsumotoHideo Baba
Jul 3, 2021·Cancers·Caroline Gronnier, Denis Collet
Aug 25, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Swathikan ChidambaramSheraz R Markar
Sep 5, 2021·Annals of Surgical Oncology·Kazumasa FujitaniUNKNOWN Osaka University Clinical Research Group for Gastroenterological Surgery

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