Abstract
To evaluate the role of survivin and caspase-3 in apoptosis of gastric carcinoma, as well as in prognosis of patients with gastric carcinoma. Expressions of survivin and caspase-3 were investigated immunohistochemically in 80 gastric carcinoma patients without a history of chemo-radiation therapy. Tumor cell apoptosis was examined by TUNEL method. Immunohistochemical analysis showed that survivin expression was positive in 61 of 80 patients (76%) with gastric carcinoma. In contrast, no expression of survivin in adjacent normal tissues was detected. Expression level of caspase-3 was higher in normal tissues than in carcinoma. Patients with higher expression of survivin had worse histological grades and pathological stages. Expression of caspase-3 was significantly associated with histological stages, but not with the pathological stages. Although survivin expression in carcinoma was not inversely related to caspase-3, patients with survivin (-) and caspase-3(+) had the maximum apoptosis index. Expression level of survivin was associated with histological grades and pathological stages of the tumor, indicating that survivin may be a poor prognosis factor for gastric carcinoma. Unlike caspase-3, survivin (an apoptosis inhibitor) c...Continue Reading
References
Jan 25, 1991·Cell·M Cross, T M Dexter
Dec 29, 1995·Cell·B A HayG M Rubin
Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
May 9, 1998·The Journal of Biological Chemistry·R TakahashiJ C Reed
Apr 29, 1998·Science·M Barinaga
Jun 25, 1998·The Journal of Cell Biology·H P HauserS Jentsch
Dec 22, 1998·Nature·F LiD C Altieri
Feb 13, 1999·The Journal of Biological Chemistry·X M SunG M Cohen
Jul 17, 1999·Trends in Cell Biology·L K Miller
Nov 5, 1999·Nature·C SunS W Fesik
Aug 10, 2000·Nature Structural Biology·Y Shi
Nov 28, 2000·Japanese Journal of Cancer Research : Gann·K AsanumaN Watanabe
Dec 7, 2000·Medical and Pediatric Oncology·A IslamA Nakagawara
Oct 3, 2001·The Journal of Clinical Investigation·J C Reed
Oct 26, 2001·Journal of Neurochemistry·S L ShankarB Shafit-Zagardo
Apr 26, 2002·Gynecologic Oncology·Hiromasa SasakiBenjamin K Tsang
Citations
Nov 28, 2012·Steroids·Erin L ScottDarrell W Brann
Aug 2, 2011·Human Pathology·Gonzalo Rodríguez-BerrigueteMar Royuela
Jan 6, 2016·Pharmaceutical Biology·Ti ChenJian Zhang
Feb 2, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H JiangT Y Wang
Dec 20, 2005·Human Pathology·Anna ParentiVito Ninfo
Sep 1, 2012·Polski przeglad chirurgiczny·Jarosław BuryGrzegorz Wallner
Jan 6, 2017·Scientific Reports·Wei PengChun-Jie Wu
May 4, 2006·International Journal of Cancer. Journal International Du Cancer·Antonio RosatoPaola Zanovello
Mar 30, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Huihua XiongHua Xiong
Jan 24, 2019·Biomarkers in Medicine·Ziba Nariman-Saleh-FamJavad Tavakkoli-Bazzaz
Jun 15, 2007·Histopathology·G-Y ChauY-P Chau
Oct 30, 2007·Journal of Cancer Research and Clinical Oncology·Jonathan C M ClarkPeter F M Choong
Nov 5, 2011·Cell Biochemistry and Biophysics·Zhao WenyingSheng Lili
Jul 31, 2019·Natural Product Research·Qinghu WangWenqiang Bao
Jul 9, 2014·Cell Biochemistry and Biophysics·Bing LiBaoqing Jia
Aug 22, 2018·Oncology Letters·Yanfeng LiHongyan Qu
Dec 21, 2005·The Journal of Nutrition·Chun LiuXiang-Dong Wang
Oct 13, 2012·Experimental and Therapeutic Medicine·Hong-Sheng LinGuo-Wei Zhang
Aug 30, 2017·Molecular Medicine Reports·Qing-Jian OuYu-Jing Fang
Jan 19, 2018·Oncology Letters·Li-Li MeiZhi-Zhou Shi
Oct 4, 2020·Clinical Orthopaedics and Related Research·Saied MirshahidiLee M Zuckerman
Nov 2, 2013·Oncology Letters·Li-Jun XiaoHua-Chuan Zheng
Jun 26, 2020·Journal of Gastrointestinal Cancer·Mayara Luciana SallasLucas Trevizani Rasmussen