Influence of sympathectomy in humans on the rhythmicity of 6-sulphatoxymelatonin urinary excretion

Molecular and Cellular Endocrinology
Morten MøllerMichael Grønbech-Jensen

Abstract

The amount of 6-sulphatoxymelatonin, the chief metabolite of melatonin, in the urine was measured in nine patients, who were subjected to bilateral sympathectomy at the second thoracic ganglionic level for treatment of hyperhidrosis of the palms. All patients showed before surgery a normal 6-sulphatoxymelatonin excretion with a peak in the excretion during the night time. After the sympathectomy, the high night time excretion was clearly abolished in five patients but remained high in four patients. This indicates that the segmental locations of the preganglionic sympathetic perikarya in the spinal cord, stimulating the melatonin secretion in the pineal gland in humans, vary between individuals. An increase in daytime melatonin excretion was observed in the patients responding to the sympathectomy with an abolished 6-sulphatoxymelatonin rhythm. This increase could indicate that the final sympathetic neurons innervating the pineal gland might have a both stimulatory and inhibitory function.

References

Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D C KleinR Y Moore
Sep 1, 1999·Microscopy Research and Technique·M Møller
Jun 14, 2000·The Journal of Clinical Endocrinology and Metabolism·J M ZeitzerC A Czeisler
Jul 12, 2002·Cell and Tissue Research·Morten Møller, Florian M M Baeres
Jan 1, 1960·Zeitschrift für Zellforschung und mikroskopische Anatomie·J A KAPPERS
Feb 27, 2004·The Journal of Comparative Neurology·Chiara FabrisMorten Møller
Jan 15, 2005·Sleep Medicine Reviews·Frank A J L Scheer, Charles A Czeisler
Feb 5, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hyun Min ChoSook Whan Sung

❮ Previous
Next ❯

Citations

Jul 17, 2009·Pharmacological Reports : PR·Jolanta B ZawilskaJosephine Arendt
Sep 10, 2008·Experimental Eye Research·Laura L KlittenMorten Møller
Apr 24, 2014·BioMed Research International·Morten MøllerCorin Badiu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

Cell and Tissue Research
Morten Møller, Florian M M Baeres
The Journal of Clinical Endocrinology and Metabolism
H IguchiH Ibayashi
European Archives of Psychiatry and Neurological Sciences
M HajekG Fink
© 2022 Meta ULC. All rights reserved