Influence of sympathomimetic drugs (1-phenyl-2-amino-ethan-1-ol derivatives) on the biosynthesis of prostaglandins and thromboxane B2

British Journal of Pharmacology
W Förster, K Pönicke

Abstract

1--The influence of substituted 1-phenyl-2-amino-ethan-1-ols on prostaglandin and thromboxane biosynthesis was studied using ram seminal vesicle microsomes and homogenates of rat lung and of rat stomach fundus. 2--Clear structure-activity relationships were to be seen regarding the effects of sympathomimetic drugs on prostacyclin (PGI2) biosynthesis in the rat stomach fundus homogenates. 3'- and 4'-Monohydroxy-phenyl derivatives as well as 3',4'-dihydroxy-phenyl derivatives stimulated prostaglandin and thromboxane B2 (TXB2) biosynthesis. Contrary to this the 3',5'-dihydroxy-phenyl derivatives orciprenaline, terbutaline and fenoterol were inhibitors of the biosynthesis in rat organ homogenates. 3--All the sympathomimetic drugs tested stimulated cyclo-oxygenase. Orciprenaline suppressed the adrenaline-activated cyclo-oxygenase in a dose-dependent manner. 4--The effects of adrenoceptor antagonists were also studied. Phenoxybenzamine had little effect on cyclo-oxygenase activity whereas phentolamine markedly increased the rate of oxygen uptake. Both the (+)- and (-)-optical isomers of propranolol had no effect on either basal or adrenaline-stimulated oxygen uptake. In contrast, the (+)- and (-)-isomers of pindolol inhibited basal a...Continue Reading

References

May 25, 1977·Biochimica Et Biophysica Acta·F J Van der OuderaaD A Van Dorp
Dec 20, 1973·Biochimica Et Biophysica Acta·D H Nugteren, E Hazelhof
Jan 1, 1980·British Journal of Pharmacology·K E BlassK Pönicke
Jan 1, 1980·Zentralblatt Für Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Zweite Naturwissenschaftliche Abteilung: Mikrobiologie Der Landwirtschaft Der Technologie Und Des Umweltschutzes·G Müller, I Förster
Jul 15, 1964·Biochimica Et Biophysica Acta· VAN DORPDH VONKEMAN

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Citations

Apr 1, 1986·Prostaglandins·M A Balaa, D W Powell
Aug 1, 1995·Critical Care Medicine·H U StrohmengerM Georgieff

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