PMID: 6160205Dec 1, 1980Paper

Influence of synchronized sleep on the biosynthesis of RNA in neuronal and mixed fractions isolated from rabbit cerebral cortex

Journal of Neurochemistry
A GiudittaA Vitale-Neugebauer

Abstract

Adult male rabbits implanted with dural electrodes were injected intraventricularly with [3H]orotate and killed 1 h later. During the period of incorporation they were left undisturbed while their EEG activity was continuously monitored. In the fraction of neuronal perikarya prepared from cerebral cortex by a method developed by Satake and Abe in 1966, the relative content of radioactive RNA of the nuclear particulate showed a twofold increase in the transition from 0 to 100% synchronization. On the other hand, a slight but significant decline was observed in the corresponding cytoplasmic compartment. A marked increase in the relative content of radioactive RNA was similarly observed in the nuclear particulate prepared from the mixed cellular fraction. The corresponding cytoplasmic compartment showed a nonsignificant increase. These results indicate that during sleep neuronal nuclei accumulate newly synthetised RNA (presumably hnRNA) at a faster rate. Under the same conditions the process of RNA transfer to the cytoplasm (presumably rRNA) may be reduced. These effects may be only partly shared by other cerebral cells.

References

Aug 1, 1970·Journal of Neurochemistry·A Vitale-NeugebauerS Giaquinto
Oct 1, 1967·Brain Research·P Volpe, A Giuditta
Jan 1, 1967·Progress in Nucleic Acid Research and Molecular Biology·H Hydén
Nov 1, 1953·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O H LOWRY

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Citations

Sep 1, 1986·Pharmacology, Biochemistry, and Behavior·A GiudittaH Hyden
Jul 1, 1995·Behavioural Brain Research·A GiudittaS Vescia
Jul 1, 1995·Behavioural Brain Research·P Maquet
May 29, 1998·Brain Research. Molecular Brain Research·C Cirelli, G Tononi
Apr 10, 2003·Progress in Neurobiology·Joel H Benington, Marcos G Frank
Feb 2, 2006·Pediatric Rehabilitation·T T Dang-VuP Maquet
Nov 13, 2008·Journal of Cellular Biochemistry·Jacqueline VazquezMary Ann Greco
Sep 14, 2013·Current Biology : CB·Ted AbelMatthew P Walker
Aug 22, 2006·Sleep Medicine Reviews·Chiara Cirelli
Jan 1, 1982·Journal of Neurochemistry·C Perrone-CapanoA Giuditta
Apr 17, 2013·Physiological Reviews·Björn Rasch, Jan Born

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