PMID: 9429210Jan 1, 1997Paper

Influence of T-helper cell subsets and crossregulation in hepatitis B virus infection

Journal of Viral Hepatitis
D R Milich

Abstract

Serological and biochemical studies indicate that acute HBV infection is resolved in the context of an efficient cell-mediated immune (CMI) response, whereas, chronic infection is characterized by weak to undetectable CMI responses and relatively efficient humoral immunity. Because humoral immunity and CMI are regulated by different TH subsets, factors which influence the induction of TH1 vs TH2 cells specific for the HBV nucleocapsid antigens (HBcAg, HBeAg) were examined in a murine model system. The factors which affected the HBc/HBeAg-specific TH1/TH2-cell balance included: (1) the structure of the antigen (i.e. HBcAg vs HBeAg); (2) the host MHC and T-cell site recognized; (3) crossregulation between TH1 and TH2 cells; (4) T-cell tolerance, which is more complete in TH1 than in TH2 cells; (5) secreted HBeAg, which preferentially depletes TH1 cells; (6) the HBV-specific subset response could be skewed towards either TH1 or TH2 predominance by cytokine treatment in vivo. The results suggest that the balance between TH1 and TH2 cells specific for the HBc/HBeAgs may be relevant in acute and chronic HBV infections. Importantly, HBeAg-specific TH2 cells preferentially evade tolerance induction as compared to their TH1-cell counter...Continue Reading

References

Apr 10, 1975·The New England Journal of Medicine·C E StevensW C Lee
Oct 19, 1992·Journal of Immunological Methods·T MaruyamaD R Milich
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A BertolettiF V Chisari
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D R MilichJ E Jones
Jun 13, 1991·The New England Journal of Medicine·T J LiangE Ben-Porath
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M R BrunettoH Will
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D R MilichA McLachlan
Jan 17, 1989·Journal of Immunological Methods·T R Mosmann, T A Fong
Mar 1, 1982·Pediatric Research·K ArakawaM Mayumi
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D R MilichJ E Jones
Jan 28, 1994·Cell·W E Paul, R A Seder
Jun 1, 1993·The Journal of Clinical Investigation·T MaruyamaD R Milich

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Citations

Jul 30, 2002·The Lancet Infectious Diseases·Pierre Vandepapelière
Oct 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Margaret T ChenDavid R Milich
Feb 15, 2005·Journal of Virology·Margaret ChenDavid R Milich
Jul 4, 2009·World Journal of Gastroenterology : WJG·Ying-Hui Shi, Chang-He Shi
Feb 7, 2002·Expert Opinion on Investigational Drugs·William DelaneyStephen A Locarnini
Jul 12, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi NowatariNobuhiro Ohkohchi
Dec 2, 2000·Journal of Gastroenterology and Hepatology·S Locarnini
Jan 1, 2015·Biomédica : revista del Instituto Nacional de Salud·Julio-C RendónMaría Cristina Navas
Oct 6, 1998·Nature·R NicksonM Rahman
Jun 1, 2006·The Journal of Pharmacy and Pharmacology·M E Christine LutsiakJohn Samuel
Jun 25, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·H Y KimY B Lee
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A OhtaT Nishimura
Jul 23, 2005·World Journal of Gastroenterology : WJG·Na LinXiao-Zhong Wang

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