Influence of tablet hardness and hydrophobicity on the adhesive properties of an acrylic resin copolymer

Pharmaceutical Development and Technology
Linda A Felton, James W McGinity

Abstract

The adhesive properties--including the force of adhesion, elongation at adhesive failure, the modulus of adhesion, and the adhesive toughness--of an acrylic resin copolymer were determined using the butt adhesion technique. Flat-faced tablets containing up to 30% hydrogenated castor oil were coated with an aqueous dispersion of Eudragit L30D-55. Using data obtained from a Chatillon digital force gauge attached to a motorized test stand, force-deflection profiles, similar to stress-strain curves generated in the tensile testing of free films, were constructed. The surface characteristics of the tablets significantly influenced polymer-substrate interaction. The force of adhesion, the elongation at adhesive failure, and the adhesive toughness decreased as the surface of the tablet became more hydrophobic through the addition of wax to the tablet formulation. Lower adhesive properties were found with increasing tablet hardness, due to a decrease in the effective area of contact between the film coating and the tablet surface. Increased polymer loading resulted in stronger adhesion, indicating a relationship between the mechanical and adhesive properties of the polymer. The present study demonstrated that the area under the force-d...Continue Reading

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Citations

Jan 10, 2008·AAPS PharmSciTech·Linda A Felton
Feb 21, 2002·Pharmaceutical Development and Technology·Linda A Felton, W Lee Perry
Mar 21, 2006·Pharmaceutical Development and Technology·L A Felton, G S Timmins
Jan 7, 2010·Drug Development and Industrial Pharmacy·Stuart C Porter, Linda A Felton
Jan 24, 2013·Expert Opinion on Drug Delivery·Linda A Felton, Stuart C Porter
Apr 29, 1999·Drug Development and Industrial Pharmacy·L A Felton, J W McGinity
May 25, 2002·Drug Development and Industrial Pharmacy·Linda A Felton, James W McGinity
Apr 18, 2016·International Journal of Pharmaceutics·Leena Kumari PrasadRobert O Williams
Mar 15, 2001·Pharmaceutical Development and Technology·L A Felton, M L Baca
Mar 22, 2005·Pharmaceutical Development and Technology·Heena KhanGraeme S Macleod
Jun 9, 2011·Pharmaceutical Development and Technology·Christine CahyadiPaul Wan Sia Heng
Jul 11, 2012·International Journal of Pharmaceutics·Fridrun Podczeck
Jun 11, 2016·International Journal of Pharmaceutics·Elena Macchi, Linda A Felton
Jun 12, 2012·International Journal of Pharmaceutics·Lucia ZemaAndrea Gazzaniga
Jan 24, 2018·Drug Development and Industrial Pharmacy·Linda A Felton

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