Influence of TachoComb in comparison to local hemostyptic agents on epidural fibrosis in a rat laminectomy model

Minimally Invasive Neurosurgery : MIN
J-Y LeeN Klug

Abstract

This animal experimental study was designed to examine the effects of TachoComb, a fixed combination of collagen with tissue adhesive, as an interposition membrane on the development of spinal epidural fibrosis in comparison to other hemostyptic materials. In 10 Wistar rats, four laminectomies were performed at lumbar and sacral vertebrae. Alternately, a piece of TachoComb, Spongostan, or Tabotamp was placed into each laminectomy site. One laminectomy site served as an empty control (n = 10). 8 weeks later, the animals were sacrificed, and the spinal column including surrounding muscle tissue was removed en bloc from each rat and fixed in formaldehyde. After decalcification and staining the specimens were graded by a neuropathologist in a blindfold test for severity of epidural fibrosis as "light-moderate" or "marked". Epidural scarring of variable density was seen in all laminectomy sites. Light epidural fibrosis, without any adhesion to dura, as only noted in cases after application of TachoComb (n = 4/10) and Spongostan (n = 1/10). All other slices showed marked epidural fibrosis with dura adherence regardless of the implanted material. Statistical analysis revealed significantly lower epidural fibrosis after application of ...Continue Reading

Citations

Oct 14, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Marek SzpalskiBernard Sztern
Jan 30, 2004·Journal of Neurosurgery·Jin-Yul LeeNorfrid Klug
Jul 21, 2006·Journal of Neurosurgery. Spine·Jin-Yul LeeNorfrid Klug
Oct 22, 2008·Journal of Neurosurgery. Spine·Suat E CelikZiya Kapran
Feb 15, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Majid Reza FarrokhiAtefeh Bakhtazad
Jun 17, 2009·Expert Opinion on Biological Therapy·Andreas RickenbacherAndrea Frilling
Jun 18, 2009·British Journal of Neurosurgery·Berker CemilIbrahim Tekdemir
Nov 20, 2015·The Spine Journal : Official Journal of the North American Spine Society·Selin Tural EmonAdnan Somay
Mar 11, 2009·The Spine Journal : Official Journal of the North American Spine Society·Lisa S KloppSimon Turner
Mar 4, 2014·Orthopedics·Neil V Shah, Robert Meislin
Nov 15, 2014·Journal of Neurosurgery. Spine·Semra IsıkSeref Dogan
Dec 1, 2006·The Journal of International Medical Research·G DickneiteD Rosenthal

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