PMID: 3756193Sep 12, 1986Paper

Influence of tauroursodeoxycholic and taurodeoxycholic acids on hepatic metabolism and biliary secretion of phosphatidylcholine in the isolated rat liver

Biochimica Et Biophysica Acta
D AlvaroR Utili

Abstract

Studies were carried out using an isolated rat liver system to define: the contribution of exogenous phosphatidylcholine (PC) to biliary phospholipid secretion; and its hepatic metabolism during perfusion of the livers with conjugated bile salts with different hydrophilic/hydrophobic properties. A tracer dose of sn-1-palmitoyl-sn-2-[14C]linoleoylPC was injected as a bolus into the recirculating liver perfusate, under constant infusion of 0.75 mumol/min of tauroursodeoxycholate or taurodeoxycholate. The effects on bile flow, biliary lipid secretion, 14C disappearance from the perfusate and its appearance in bile, as well as hepatic and biliary biotransformation were determined. With both the bile salts, about 40% of the [14C]PC was taken up by the liver from the perfusate over 100 min. During the same period less than 2% of the given radioactivity was secreted into bile. More than 95% of the 14C recovered in bile was located within the identical injected PC molecular species. The biliary secretion of labeled as well as unlabeled PC, however, was significantly higher in livers perfused with taurodeoxycholate than tauroursodeoxycholate, while the reverse was observed with respect to bile flow and total bile salt secretion. The exo...Continue Reading

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Mar 17, 1992·Biochemical Pharmacology·J V RodriguezC Tiribelli
May 1, 1993·Archives of Gerontology and Geriatrics·A CantaforaR Verna
Jun 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·R MasellaA Cantafora
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Nov 27, 1987·Biochimica Et Biophysica Acta·M AngelicoA Cantafora
Apr 23, 1992·Biochimica Et Biophysica Acta·R Coleman, K Rahman

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