Abstract
Plague, caused by the flea-transmitted bacterial pathogen Yersinia pestis, is primarily a disease of wild rodents distributed in temperate and tropical zones worldwide. The ability of Y. pestis to develop a biofilm blockage that obstructs the flea foregut proventriculus facilitates its efficient transmission through regurgitation into the host bite site during flea blood sucking. While it is known that temperature influences transmission, it is not well-known if blockage dynamics are similarly in accord with temperature. Here, we determine the influence of the biologically relevant temperatures, 10 and 21°C, on blockage development in flea species, Xenopsylla cheopis (Rothschild) and Oropsylla montana (Baker), respectively, characterized by geographical distribution as cosmopolitan, tropical or endemic, temperate. We find that both species exhibit delayed development of blockage at 10°C. In Y. pestis infected X. cheopis, this is accompanied by significantly lower survival rates and slightly decreased blockage rates, even though these fleas maintain similar rates of persistent infection as at 21°C. Conversely, irrespective of infection status, O. montana withstand 21 and 10°C similarly well and show significant infection rate in...Continue Reading
References
Dec 15, 1971·Journal of Medical Entomology·R E Ryckman
Mar 1, 1971·The American Journal of Tropical Medicine and Hygiene·D C Cavanaugh
Jan 1, 1969·Transactions of the Royal Society of Tropical Medicine and Hygiene·L Kartman
Jul 19, 1996·Science·B J HinnebuschT G Schwan
Sep 1, 1996·Journal of Medical Entomology·J D Lang
Oct 17, 1998·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A E MuchlinskiR Gramajo
Dec 10, 1999·The American Journal of Tropical Medicine and Hygiene·R R ParmenterK L Gage
Mar 5, 2004·Journal of Bacteriology·Robert D PerryJacqueline D Fetherston
Jul 24, 2004·The Journal of Infectious Diseases·Clayton O JarrettB Joseph Hinnebusch
May 5, 2005·The Journal of Infectious Diseases·Ellen A LorangeB Joseph Hinnebusch
Oct 31, 2007·Advances in Experimental Medicine and Biology·Alexander G BobrovRobert D Perry
Aug 4, 2009·Journal of Medical Entomology·Rebecca J EisenKenneth L Gage
May 1, 1908·The Journal of Hygiene
Aug 1, 1947·The Journal of Hygiene·A L Burroughs
May 12, 2011·PloS One·Yi-Cheng SunB Joseph Hinnebusch
Sep 29, 2011·PLoS Pathogens·Tamara Ben-AriNils Chr Stenseth
Oct 1, 2011·Parasites & Vectors·Anna M SchotthoeferKenneth L Gage
Apr 18, 2013·Vector Borne and Zoonotic Diseases·Shanna K WilliamsScott W Bearden
May 17, 2014·Cell Host & Microbe·Yi-Cheng SunB Joseph Hinnebusch
Jan 15, 2015·Environmental Microbiology·Alexander G BobrovRobert D Perry
May 1, 2015·Parasites & Vectors·Yujiang ZhangYajun Song
Feb 2, 2016·PLoS Neglected Tropical Diseases·David M Bland, B Joseph Hinnebusch
Jan 13, 2017·PLoS Neglected Tropical Diseases·B Joseph HinnebuschClayton O Jarrett
Sep 10, 2017·Annual Review of Microbiology·B Joseph HinnebuschDavid M Bland
Jan 23, 2018·PLoS Pathogens·David M BlandB Joseph Hinnebusch
Jun 10, 2019·Methods in Molecular Biology·Athena LemonViveka Vadyvaloo