Influence of testosterone and dihydrotestosterone on bone-matrix induced endochondral bone formation

Calcified Tissue International
S P Kapur, A H Reddi

Abstract

A bone matrix-induced endochondral bone development model has been used to study the effects of androgens on different stages of bone development in castrated young adult rats. Androgen treatment, especially with dihydrotestosterone (DHT) for 7 days, inhibited 35SO4 incorporation by the developing cartilage in the induced plaques. Castrated control animals maintained for 11 days after implantation of bone matrix showed significantly lower calcium levels in the induced implant than was observed earlier in the unoperated controls. DHT treatment for 11 days caused dramatic increases in levels of calcium in the implants. Testosterone had little effect. When androgen treatment was continued for 21 days, while levels of alkaline phosphatase in the implants were unaffected, levels of calcium in the implants were significantly higher than on day 11 for both castrated control and androgen-treated animals. Peak alkaline phosphatase activity (day 10) is known to precede peak calcium mineralizing activity (day 12) in this model and it is also known that calcium levels remain high thereafter. Evaluation of calcium and alkaline phosphatase levels in the proximal tibial metaphyses of castrated control and androgen-treated groups of animals sh...Continue Reading

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References

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Citations

Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, E Gold
Sep 1, 1993·Calcified Tissue International·P T PrisellG Norstedt
May 20, 1999·Baillière's Clinical Endocrinology and Metabolism·L Katznelson
Feb 17, 2000·The Journal of Veterinary Medical Science·S Fukuda, H Iida
Jan 10, 2002·Revista do Hospital das Clínicas·E M Frade CostaB B Mendonca
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Jun 8, 2004·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Feb 2, 2006·Journal of Cell Science·Stephen C GilliverGillian S Ashcroft

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