Influence of testosterone substitution on glycemic control and endothelial markers in men with newly diagnosed functional hypogonadism and type 2 diabetes mellitus: a randomized controlled trial

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
Irina KhripunMichael Zitzmann

Abstract

Effects of testosterone (T) on the cardiovascular system of men remain controversial. The impact of T-replacement therapy (TRT) in men with functional hypogonadism and type 2 diabetes mellitus (T2DM) has to be elucidated. This study included 80 men (mean age 51.5 ± 6.3 years) with newly diagnosed T2DM (according to ADA criteria) and functional hypogonadism (according to EAU criteria). Randomization: Group1 (n = 40): TRT using 1%-transdermal T-gel (50 mg/day), Group2 (n = 40) no TRT (controls). Dietary treatment applied to both. Parameters at baseline/after 9 months: anthropometric parameters, lipids and indicators of carbohydrate metabolism (fasting glucose, insulin, HbA1c, HOMA-IR), markers of adipose tissue and EnD (leptin, resistin, p- and e-selectin, ICAM- 1, VCAM- 1 and CRP). ANCOVA for repeated measurements revealed TRT to cause a significant decrease in waist circumference (WC), HOMA-IR and HbA1c vs controls (p < .001, p = .002, p = .004, respectively). Leptin declined in subjects receiving TRT vs controls (p = .04). Concentrations of resistin, ICAM-1, p-selectin and CRP decreased significantly vs controls (all p < .001); no effects for e-selectin and VCAM-1. Advanced age attenuated effects, higher delta testosterone lev...Continue Reading

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Citations

Nov 23, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Suleyman Sami CakirEmin Ozbek
Mar 30, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Pin-Wen LiaoChen-Hsun Ho
Jan 18, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jianzhong ZhangBin Yang
Jun 3, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jinze LiQiang Wei
Jun 30, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Satilmis BilginHaluk Savli
Aug 28, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kristina Groti AntoničMarija Pfeifer
Jun 4, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·M Zahid KocakHaluk Savli
Jan 18, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Monica Caliber, Geoff Hackett
Nov 18, 2020·Journal of Diabetes Investigation·Shengnan SunYangang Wang
Mar 24, 2020·Sexual Medicine·Omer Faruk KirlangicSerap Gur
Jun 5, 2021·Expert Review of Clinical Pharmacology·Giovanni CoronaMario Maggi

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