Influence of the blood bacterial load on the meningeal inflammatory response in Streptococcus pneumoniae meningitis.

BMC Infectious Diseases
Christian ØstergaardJens D Lundgren

Abstract

Despite bacteraemia is present in the majority of patients with pneumococcal, little is known about the influence of the systemic infection on the meningeal inflammatory response. To explore the role of systemic infection on the meningeal inflammation, experimental meningitis was induced by intracisternal injection of approximately 1 x 10(6) CFU Streptococcus pneumoniae, type 3, and the 26 rabbits were either provided with approximately 1 x 10(6) CFU S. pneumoniae intravenously at 0 hour ("bacteraemic" rabbits, n = 9), immunized with paraformaldehyde-killed S. pneumoniae for 5 weeks prior to the experiment ("immunized" rabbits", n = 8), or not treated further ("control" rabbits, n = 9). WBC and bacterial concentrations were determined in CSF and blood every second hour during a 16 hours study period together with CSF IL-8 and protein levels. We also studied CSF and blood WBC levels in 153 pneumococcal meningitis patients with and without presence of bacteraemia. As designed, blood bacterial concentrations were significantly different among three experimental groups during the 16 hours study period (Kruskal Wallis test, P < 0.05), whereas no differences in CSF bacterial levels were observed (P > 0.05). Blood WBC decreased in bac...Continue Reading

References

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Citations

Jan 5, 2008·The Journal of Infectious Diseases·Christian T BrandtIan J Rowland
Jul 8, 2011·Clinical Microbiology Reviews·Barry B Mook-KanamoriDiederik van de Beek
Jan 5, 2010·BMC Infectious Diseases·Christian ØstergaardChristian T Brandt
Jun 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michael PedersenKirsten Møller

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Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism
SAS
JMP
GraphPad

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