Influence of the blood group reactive substances in saliva on the aggregation of Streptococcus rattus

Antonie van Leeuwenhoek
A J LigtenbergA V Nieuw Amerongen

Abstract

The interaction of blood group reactive substances in saliva with bacteria was investigated by testing saliva from persons with different blood groups in a bacterial aggregation assay with Streptococcus rattus HG 59, originally S. rattus BHT. For blood group A, saliva from 10 persons out of 11 aggregated S. rattus and for blood group O, saliva from 10 persons out of 16 aggregated S. rattus. For blood group B, saliva from 6 persons out of 8 aggregated S. rattus weakly and the average aggregation activity of blood group B was much lower than for blood group A or O. In addition, saliva from 3 non-secretors did not aggregate S. rattus. The role of blood group antigens in bacterial aggregation was confirmed by inhibition studies with blood group specific sugars and various other sugars. GalNAc, specific for blood group A, inhibited bacterial aggregation by saliva whereas D-galactose, specific for blood group B, and D-fucose, specific for blood group O, did not. In addition, sialic acid, a major terminal sugar residue in mucins, also inhibited the bacterial aggregation. This study shows that the blood group and secretor status of a person may influence the interaction of saliva with bacteria in the oral cavity.

References

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Citations

May 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A V Nieuw AmerongenE C Veerman
Jan 1, 2010·International Journal of Molecular Sciences·A J LigtenbergE C Veerman
Jan 1, 1993·Antonie van Leeuwenhoek·A J LigtenbergA V Nieuw Amerongen
Mar 2, 2011·International Journal of Dental Hygiene·S T Tabasum, R P Nayak
Oct 17, 2009·Oral Microbiology and Immunology·A NistorYvonne Myal
Jan 1, 1990·Archives of Oral Biology·A J LigtenbergA V Nieuw Amerongen
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Sep 7, 2016·Pathogens and Disease·Dharmaprakash ViszwapriyaShunmugiah Karutha Pandian
Jan 1, 1994·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·F A Scannapieco

Related Concepts

Acetylgalactosamine
Blood Group Antigens
Galactose
Saliva
Sialic Acids
Streptococcus

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