Influence of the conceptuses and the maternal pituitary on the distribution of multiple components of serum relaxin immunoactivity during pregnancy in the rat

Endocrinology
O D SherwoodR H Key

Abstract

Relaxin isolated from the ovaries of pregnant rats has a mol wt of 6,500; however, relaxin immunoactivity (RI) in the peripheral serum of pregnant rats is associated with three major components. Essentially all RI is associated with a large component (C1, mol wt approximately 60,000) on day 15 of pregnancy (day 15), but the distribution shifts progressively so that about 50% of the RI is associated with two smaller components (C2, mol wt approximately 13,000; C3, mol wt approximately 6,500) by day 19. The present study examined factors that might influence the distribution of RI among these three components. The distribution of RI in sera from ovarian vein and abdominal aorta on days 16 and 19 was compared after gel filtration through Sephacryl S-200. The distribution of RI among the three major components was similar for sera collected from the two sources. It is concluded that the progressive shift in the distribution of RI among the three major components during late pregnancy is attributable to dynamic changes in their secretion, rather than peripheral metabolism of relaxin after its release from the ovary. This study also determined the influence of the conceptuses and the maternal pituitary on the distribution of RI. The ...Continue Reading

Citations

Sep 7, 2000·Biochemical and Biophysical Research Communications·Y FujitaS Natori
Dec 22, 1989·Biochimica Et Biophysica Acta·A KobayashiS Natori
Oct 9, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Lais Cavalca CardosoMaria Fatima Magalhaes Lazari
May 2, 2006·Pharmacology & Therapeutics·Thomas DschietzigKarl Stangl
Sep 25, 2021·Veterinary Research Communications·Leying ZhangLing Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.