PMID: 16645444Apr 29, 2006Paper

Influence of the descending thoracic aortic cross clamping on bispectral index value and plasma propofol concentration in humans

Anesthesiology
Manabu KakinohanaKazuhiro Sugahara

Abstract

In this study, the authors investigated changes in Bispectral Index (BIS) values and plasma propofol concentrations (Cp) after aortic cross clamping in the descending thoracic aortic aneurysm repair surgery during propofol anesthesia. Prospectively, in 10 patients undergoing thoracic aortic surgery during total intravenous anesthesia with propofol, BIS values were recorded during cross clamping of the descending thoracic aorta. In this study, the rate of propofol infusion was controlled to keep the BIS value between 30 and 60 throughout surgery. Simultaneously, Cp values in the blood samples taken from the right radial artery (area proximal to cross clamping) and the left femoral artery (area distal to cross clamping) were measured. Approximately 15 min after initiating aortic cross clamping, BIS values in all cases started to decrease abruptly. Cp values of samples taken from the radial artery after cross clamping of the aorta were significantly (P < 0.05) increased compared with pre-cross clamp values (1.8 +/- 0.4 microg/ml), and the mean Cp after aortic cross clamping varied between 3.0 and 5.3 microg/ml. In addition, there were significant differences in the Cp values between radial arterial and femoral arterial blood sampl...Continue Reading

References

Oct 20, 1998·Anesthesiology·I J Rampil
Oct 24, 2001·Anaesthesia and Intensive Care·M T Kluger
Dec 18, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S MératJ J Hoffmann
May 7, 2002·British Journal of Anaesthesia·B SzekelyM Fischler
Nov 1, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·N UmegakiA Mtasuki
Jan 28, 2005·Anesthesia and Analgesia·Thomas M HemmerlingIgnatio Prieto

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Citations

Jul 7, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·L BeydonM Gogny
May 15, 2012·Pharmacological Reports : PR·Paweł WiczlingEdmund Grześkowiak
Oct 13, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Takayuki KunisawaHiroshi Iwasaki
Oct 21, 2019·Journal of Anesthesia·Masahiko KawaguchiUNKNOWN MEP Monitoring Guideline Working Group of the Safety Committee of the Japanese Society of Anesthesiologists (JSA)

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