PMID: 6976659Oct 1, 1981Paper

Influence of the gut microflora on the metabolism of 4-nitrobenzoic acid in the marmoset

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
E J Kuzniar, S P James

Abstract

1. 4-Nitrobenzoic acid was metabolized by the marmoset to amino derivatives to the extent of 18.8% (p.o.) and 11.4% (i.p.) of the dose. 2 Reduction of 4-nitrobenzoic acid was significantly decreased by antibiotic pretreatment; the mean decrease in reduction was 81% for animals doses orally and 73% for intraperitoneally dosed marmosets. 3. 4-Nitrohippuric acid was the major metabolite of 4-nitrobenzoic acid, accounting for 30.6% and 49.6% of p.o. and i.p. doses respectively. 4. Antibiotic pretreatment affected the marmosets' normal capacity to reduce 4-nitrobenzoic acid for many weeks after the initial administration. 5. Maximum radioactivity in the blood, after an oral dose, was reached in 30-40 min; the average half-life for the elimination of 4-nitro[carboxy-14C]benzoic acid and its metabolites was 30.4 +/- 3 min after an intramuscular dose. 6. Radioactivity of 4-nitro[carboxy-14C]benzoic acid representing 3.4% of the dose was excreted in rat bile in 24 h.

References

Apr 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J R IdleR T Williams
Nov 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D M Gardner, A G Renwick
Jan 1, 1976·Biochemical Society Transactions·J R IdleR T Williams
Jan 1, 1976·Biochemical Society Transactions·D BrewsterD V Parke
Jul 1, 1970·Toxicology and Applied Pharmacology·G P Carlson, K P DuBois
Mar 1, 1971·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R GingellR T Williams
Apr 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·V Facchini, L A Griffiths
Dec 1, 1967·The Biochemical Journal·M M Abou-El-MakaremR T Williams

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Citations

Jul 16, 2010·Journal of Dairy Science·J M BesleJ B Coulon
Jan 1, 1985·Critical Reviews in Toxicology·I R RowlandA Wise
Jan 1, 1988·Critical Reviews in Food Science and Nutrition·S Rajarathnam, Z Bano

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