PMID: 3755773Jul 1, 1986Paper

Influence of the intake and composition of elemental diets on bile acid metabolism and hepatic lipids in the rat

JPEN. Journal of Parenteral and Enteral Nutrition
L M Nelson, R I Russell

Abstract

The effects of the elemental diets Vivonex (V) and Flexical (F) on bile acid metabolism and hepatic lipids in the rat has been investigated both with ad libitum feeding and when calorie intake was limited to that of control rats (C) fed a standard diet (Oxoid 41B). Ad libitum feeding of V and F for 9 weeks resulted in a weight gain in excess of that for the control diet. After 9 weeks of isocaloric feeding the V-fed rats were significantly lighter than those fed F and C. Fecal bile acid excretion (FBA) and the fractional turnover rates for cholic acid (CA) and chenodeoxycholic acid (CDC) were measured. The elemental diets significantly reduced FBA when fed both ad libitum and isocalorically compared with the control diet, the reduction with V being significantly greater than for F. In the isocaloric feeding study both elemental diets significantly increased the half life of CA and CDC. The increase for CA was significantly greater for V than F but for CDC the effect of the two diets was the same. Thus the percentage of CDC-derived 6 substituted bile acids was greater with V than F feeding. There was a strong negative correlation between bile acid half-life and fecal excretion of metabolites for the three dietary groups indicati...Continue Reading

References

Apr 21, 1979·Journal of Chromatography·W G BrydonM A Eastwood
Nov 1, 1978·Clinical Science and Molecular Medicine·L M NelsonF D Lee
Jun 1, 1976·The Journal of Surgical Research·B MainiH Y Rienhoff
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Dec 1, 1972·The American Journal of Clinical Nutrition·H R AtteberyS M Finegold
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Aug 1, 1969·The British Journal of Nutrition·B E Gustafsson, A Norman
Nov 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·E A YoungV Balderas
Jan 1, 1980·The British Journal of Nutrition·W G BrydonM E Lawson
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Aug 1, 1962·The American Journal of Clinical Nutrition·A ANTONIS, I BERSOHN

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Citations

Jun 1, 1991·Alimentary Pharmacology & Therapeutics·R I Russell

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