Influence of the mode of ventilation on ketamine/xylazine requirements in rabbits

Veterinary Anaesthesia and Analgesia
Andrey L YershovMichael A Dubick


To evaluate the effect of the mode of mechanical ventilation (MV) on the dose of intravenous anesthetic during 3 hours of ketamine/xylazine anesthesia. Prospective laboratory study. Sixty-one adult male New Zealand White rabbits. Rabbits were anesthetized (ketamine/xylazine 35 + 5 mg kg(-1), IM), the trachea was intubated and randomized to four groups - (1) CMV-1 (n = 14), ventilated with traditional conventional volume-cycled MV [V(T) = 12 mL kg(-1), RR = 20, positive end-expiratory pressure (PEEP) = 0 cmH(2)O]; (2) CMV-2 (n = 13), ventilated with a modern lung-protective regimen of volume-cycled MV (V(T) = 6 mL kg(-1), RR = 40, PEEP = 5 cmH(2)O); (3) HFPV (n = 17) ventilated with high-frequency percussive ventilation [high-frequency oscillations (450 minute(-1)) superimposed on 40 minute(-1) low-frequency respiratory cycles, I:E ratio = 1:1], oscillatory continuous positive airway pressure (CPAP) of 7-10 cmH(2)O, and demand CPAP of 8-10 cmH(2)O. (4) A fourth group, spontaneously ventilating (SV, n = 17), was anesthetized, intubated, but not ventilated mechanically. FiO(2) in all groups was 0.5. Anesthesia was maintained at a surgical plane by IV administration of a ketamine/xylazine mixture (10 + 2 mg kg(-1), as necessary) fo...Continue Reading


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Related Concepts

Dose-Response Relationship, Drug
Intravenous Injections
Intubation, Intratracheal
Chinchilla Rabbits
Mechanical Ventilation
Specific Pathogen Free
Xylazine Phosphate (1: 1)
Yohimbin Spiegel

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