Influence of the Molecular Weight and Charge of Antibiotics on Their Release Kinetics From Gelatin Nanospheres

Macromolecular Bioscience
Jiankang SongSander C G Leeuwenburgh

Abstract

In this study, we investigated the fundamental relationship between the physicochemical characteristics of antibiotics and the kinetics of their release from gelatin nanospheres. We observed that antibiotics of high molecular weight (colistin and vancomycin) were released in a sustained manner from oppositely charged gelatin carriers for more than 14 d, as opposed to antibiotics of low molecular weight (gentamicin and moxifloxacin) which were released in a burst-like manner. The release kinetics of positively charged colistin strongly correlated with the rate of the enzymatic degradation of gelatin. To elucidate the differences among release kinetics of antibiotics, we explored the mechanism of interactions between antibiotics and gelatin nanospheres by monitoring the kinetics of release of antibiotics as a function of pH, ionic strength, and detergent concentrations. These studies revealed that the interactions between antibiotics and gelatin nanospheres were mainly dominated by (i) strong electrostatic forces for colistin; (ii) strong hydrophobic and electrostatic forces for vancomycin; (iii) weak electrostatic and hydrophobic forces for gentamicin; and (iv) weak hydrophobic forces for moxifloxacin. These results confirm that...Continue Reading

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Citations

May 12, 2016·ACS Applied Materials & Interfaces·Jiankang SongSander C G Leeuwenburgh
Nov 8, 2018·Journal of Dental Research·B WangF Yang
Dec 16, 2020·ACS Biomaterials Science & Engineering·F JahanmardS Amin Yavari
Jun 6, 2017·Acta Biomaterialia·Mani DibaSander C G Leeuwenburgh

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