Influence of the number of malignant regional lymph nodes detected by endoscopic ultrasonography on survival stratification in esophageal adenocarcinoma

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Jaime ChenThomas J Savides

Abstract

The nodal staging of esophageal cancer accounts for the absence or presence of metastatic lymph nodes (N0 or N1, respectively). Surgical data suggest that patients have worse survival when esophagectomy specimens contain higher numbers of regional malignant lymph nodes. It has been proposed that the staging system for esophageal cancer be modified to include the number of malignant lymph nodes. The aim of this study was to determine the influence of the number of malignant-appearing regional lymph nodes detected on endoscopic ultrasonography (EUS) on survival in patients with esophageal adenocarcinoma. Historical case series involved patients with esophageal adenocarcinoma who underwent EUS staging at a single center between 1994 and 2004. Endoscopy reports were reviewed to determine the number of malignant-appearing periesophageal lymph nodes seen on EUS examination. Subjects were categorized as having 0, 1-2, or >2 periesophageal lymph nodes. A regional cancer registry prospectively obtained survival data. Among 85 patients with esophageal adenocarcinoma, the Kaplan-Meier curves showed distinct survival advantages in those with fewer malignant-appearing regional lymph nodes (P=.0008). The median survivals were 66 months, 14.5...Continue Reading

Citations

Jan 26, 2008·International Journal of Technology Assessment in Health Care·Suzanne M DyerStephen Blamey
Jul 4, 2012·World Journal of Surgical Oncology·Kjell K OvreboAsgaut Viste
Sep 17, 2013·Seminars in Roentgenology·Kyung Eun ShinYoung Mog Shim
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Nov 2, 2007·Advances in Surgery·Julia K LeBlancStuart Sherman
Mar 6, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John DeWittStuart Sherman
Jun 16, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C P TwineW G Lewis
May 26, 2009·Current Opinion in Gastroenterology·Thomas J Savides
Jul 26, 2008·Scandinavian Journal of Gastroenterology·Evangelos Kalaitzakis, John Meenan
Aug 5, 2015·Clinical Endoscopy·Jin Woong Cho

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