Influence of the pillar shape on the band broadening and the separation impedance of perfectly ordered 2-D porous chromatographic media

Analytical Chemistry
J De SmetG Desmet

Abstract

We report on a computational study assessing the effect of the pillar shape in perfectly ordered porous chromatographic media. Using computational fluid dynamics to compare the band broadening and flow resistance characteristics of a large number of different pillar shapes, it is found that the most axially elongated shapes yield the best chromatographic performance and that diamonds are to be preferred over ellipsoids. The former pack into a more uniform pore space and display a smaller C(s) value, whereas the latter pack into a locally constricted pore space and therefore generate a considerably larger flow resistance. For the presently considered case of a densely packed array (epsilon = 0.4), changing the pillar shape from a cylinder to a more elongated diamond, for example, reduces the minimal plate heights from h(min) = 0.84 to h(min) = 0.72, the C factor from C = 0.062 to C = 0.050, and the separation impedance from E(min) = 330 to E(min) = 220, without affecting the number of interchannel coupling points.

References

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Mar 8, 2003·Analytical Chemistry·Nico VervoortGert Desmet
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Citations

Nov 20, 2012·Analytical Chemistry·Gert Desmet, Sebastiaan Eeltink
Apr 16, 2013·Analytical Chemistry·Jeff Op De BeeckWim De Malsche
Nov 16, 2013·Analytical Chemistry·Teresa B KirchnerMichael J Sepaniak
Apr 2, 2010·Lab on a Chip·Nickolay V LavrikMichael J Sepaniak
Nov 22, 2007·Journal of Chromatography. a·Mauro De PraPeter J Schoenmakers
Aug 21, 2007·Journal of Chromatography. a·J Billen, G Desmet
Jun 14, 2008·Electrophoresis·Virginie DauriacHélène Sénéchal
Oct 30, 2010·Journal of Separation Science·Wim De MalscheGert Desmet
Nov 5, 2010·Journal of Separation Science·Xavi IllaAlbert Romano-Rodríguez
Dec 24, 2011·The Analyst·Lisa C TaylorMichael J Sepaniak
Aug 12, 2016·Analytical Chemistry·Danielle R LincolnMichael J Sepaniak
Sep 20, 2016·Analytical Chemistry·Adelina SmirnovaTakehiko Kitamori
Nov 15, 2018·Journal of Separation Science·Aleš Podgornik
Nov 22, 2007·Lab on a Chip·Wim De MalscheHan Gardeniers
Oct 20, 2005·Lab on a Chip·Reges Cezar de Andrade CostaJörg Peter Kutter
Dec 4, 2019·Mass Spectrometry Reviews·Przemyslaw MielczarekMarek Smoluch
Mar 17, 2021·Journal of Pharmaceutical and Biomedical Analysis·Takuya FujiwaraMakoto Tsunoda
Jun 19, 2008·Analytical Chemistry·Wim De MalscheGert Desmet
Jan 31, 2009·Analytical Chemistry·Joris VangeloovenGert Desmet
Jun 12, 2021·Analytical Chemistry·Xiaofei WangBo Zhang
Oct 30, 2010·Analytical Chemistry·Lisa C TaylorMichael J Sepaniak
Nov 13, 2004·Analytical Chemistry·Piotr GzilGert Desmet

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