Influence of the redox state of pyridine nucleotides on mitochondrial sulfhydryl groups and permeability transition

Archives of Biochemistry and Biophysics
Alberto BindoliMaria Pia Rigobello

Abstract

This work addresses a correlation between the redox state of pyridine nucleotides and that of sulfhydryl groups of the mitochondrial membranes. Several major observations emerge: (1) Conditions leading to an oxidation of the pyridine nucleotides such as incubation with tert-butyl hydroperoxide or acetoacetate determine a decrease of total mitochondrial sulfhydryl groups. Glutathione does not follow the same pattern since it decreases in the presence of tert-butyl hydroperoxide but not in the presence of acetoacetate. In addition, only in the presence of tert-butyl hydroperoxide is the decrease of sulfhydryl groups concomitant with a membrane protein polymerization, observed by polyacrylamide gel electrophoresis. (2) Under all conditions tested, the oxidation of sulfhydryl groups is further stimulated by the presence of calcium and phosphate ions. (3) Respiratory substrates, which prevent the swelling of mitochondria, also partially prevent the decrease of sulfhydryl groups.

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Citations

Aug 7, 2002·British Journal of Pharmacology·Maria Pia RigobelloAlberto Bindoli
May 23, 2001·The Biochemical Journal·M P RigobelloA Bindoli
Dec 19, 2012·Antioxidants & Redox Signaling·Alberto Bindoli, Maria Pia Rigobello
Feb 2, 2000·Proceedings of the Society for Experimental Biology and Medicine·R T Mallet
Feb 3, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sergey M KorotkovNils-Erik L Saris
Mar 7, 2009·Journal of Molecular and Cellular Cardiology·Andrew P Halestrap
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Jan 18, 2014·Journal of Biochemical and Molecular Toxicology·Sergey M KorotkovViktor V Furaev
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Sep 1, 2004·Free Radical Biology & Medicine·Antonio ToninelloChristoph Richter
Apr 26, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sergey M KorotkovIrina V Brailovskaya
Jul 10, 2012·Biochimica Et Biophysica Acta·Angelo VianelloMarco Zancani
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Apr 3, 2001·Free Radical Biology & Medicine·M P RigobelloA Bindoli
Oct 2, 2004·Journal of Inorganic Biochemistry·Maria Pia RigobelloAlberto Bindoli
Aug 23, 2005·Archives of Biochemistry and Biophysics·Maria Pia RigobelloAlberto Bindoli
Jul 9, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sergey M Korotkov
Apr 24, 2015·Journal of Medicinal Chemistry·Inês L MartinsAlexandra M M Antunes
Aug 28, 2021·International Journal of Molecular Sciences·Ekaterina KharechkinaAlexey Kruglov

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