Influence of the renal endothelin A system on the autoregulation of renal hemodynamics in SHRs and WKY rats

Journal of Cardiovascular Pharmacology
C BraunP Rohmeiss

Abstract

In this study, we investigated the influence of a short-term blockade of the renal endothelin A system on the autoregulation of total renal blood flow, cortical renal blood flow, and pressure-dependent plasma renin activity in spontaneously hypertensive rats (SHRs) and normotensive controls [Wistar-Kyoto (WKY) rats]. In anesthetized rats, renal blood flow was measured by a transit-time flow probe and cortical blood flow by a laser flow probe. Blood samples were taken for measurement of plasma renin activity. Renal perfusion pressure was reduced in 5-mm Hg steps by means of a servocontrolled electropneumatic device by an inflatable suprarenal cuff. During the experiments, the rats (n = 6, each group) received an intrarenal infusion of either the selective endothelin A-receptor antagonist BQ123 (3 mg/kg/h) or vehicle. We observed an improvement of total and cortical blood flow autoregulation as indicated by a shift of lower limits of autoregulation to lower threshold pressures [103 +/- 2 vs. 132 +/- 4 mm Hg compared with 98 +/- 3 vs. 120 +/- 4 mm Hg (mean +/- SEM); p < 0.01 resp. p < 0.05] in BQ123-treated SHRs, whereas BQ123 had no influence on breakpoints of autoregulation in WKY rats (p > 0.05). Pressure-dependent plasma renin...Continue Reading

References

Dec 1, 1992·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A W CowleyD L Mattson
May 1, 1991·Renal Physiology and Biochemistry·M FretschnerM Steinhausen
Feb 1, 1992·Hypertension·M F O'Rourke
Oct 1, 1990·Kidney International·J H Stein
Jul 31, 1990·Biochemical and Biophysical Research Communications·P MilnerG Burnstock
Dec 1, 1989·The American Journal of Physiology·M L ZeidelB M Brenner
Oct 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E Kohan
Apr 1, 1993·Physiological Reviews·M S Simonson
Jun 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E Ritz, D Fliser
Mar 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J BraunW H Hörl
Jan 1, 1996·Kidney International·P J WinyardA S Woolf
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E Ritz, H A Koomans

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Citations

Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst

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