Influence of the renal endothelin system on the autoregulation of renal blood flow in spontaneously hypertensive rats

Kidney & Blood Pressure Research
C BraunP Rohmeiss

Abstract

The renal endothelin (ET) system has been claimed to play an important role in the regulation of renal blood flow (RBF) and sodium excretion in primary hypertension. The aim of the present study was to investigate the contribution of the endogenous ET system in the autoregulation of total RBF, cortical blood flow (CBF), pressure-dependent plasma renin activity (PRA) and pressure natriuresis in spontaneously hypertensive rats (SHR) by means of the combined (A/B) ET-receptor antagonist, bosentan. In anesthetized rats, RBF was measured by transit-time flow probes and CBF by laser flow probes. During the experiments, the rats received an intrarenal infusion of either bosentan (1 mg/kg/h) or vehicle. Renal perfusion pressure (RPP) was lowered in pressure steps of 5 mm Hg with a servo-controlled electropneumatic device via an inflatable suprarenal cuff. Bosentan had no effect on resting RPP, CBF, PRA and renal sodium excretion, whereas RBF was lowered by 30% (p < 0.05). Furthermore after bosentan the rats revealed a complete loss of RBF autoregulation. In contrast no changes in autoregulation of CBF, pressure-dependent PRA and pressure natriuresis were observed. Our findings demonstrate a significant impairment in total RBF autoregul...Continue Reading

Citations

Aug 8, 2002·Kidney International·Masaomi NangakuRichard J Johnson
Nov 4, 2000·Expert Opinion on Investigational Drugs·R Venkataraman, J A Kellum
Jul 29, 2003·Expert Opinion on Investigational Drugs·Ramesh Venkataraman, John A Kellum
Nov 4, 2000·Expert Opinion on Investigational Drugs·T KnollP Rohmeiss
Sep 11, 2012·Seminars in Nephrology·Nicole Endlich, Karlhans Endlich

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