Influence of the renin-angiotensin system on sympathetic neurotransmission in canine skeletal muscle in vivo

Naunyn-Schmiedeberg's Archives of Pharmacology
J SchwielerP Hjemdahl

Abstract

The physiological importance of interactions between angiotensin II and sympathetic neurotransmission was studied in an in vivo model with constant flow blood perfused gracilis muscle in situ in dogs pretreated with desipramine and atropine. Sympathetic nerve stimulation-(2 and 8 Hz, 480 pulses) evoked over-flow of endogenous noradrenaline and vasoconstriction, and vasoconstrictor responses to exogenous noradrenaline (0.5 nmol, locally i.a.) were evaluated. Angiotensin converting enzyme inhibition by benazeprilat (10 mg i.v.; n = 8) reduced arterial angiotensin II levels from 26 +/- 8 to 2 +/- 1 pM and reduced mean arterial and basal muscle perfusion pressures. Subsequent resubstitution of angiotensin II (3, 30 and 90 ng kg-1 min-1 i.v.) elevated arterial angiotensin II dose-dependently (to 67 +/- 14, 622 +/- 63 and 1940 +/- 251 pM, respectively), as well as mean arterial and muscle perfusion pressures. Nerve stimulation-evoked noradrenaline overflow was unchanged following benazeprilat (-4 +/- 4 and +1 +/- 8% at 2 and 8 Hz, respectively) and during subsequent infusions of angiotensin II. Vasoconstrictor responses to nerve stimulation and exogenous noradrenaline were also uninfluenced by these treatments. Thus, angiotensin II d...Continue Reading

References

Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Oct 1, 1989·Journal of Cardiovascular Pharmacology·H Majewski
Oct 1, 1989·Journal of Hypertension·K F HilgersJ F Mann
May 1, 1985·Hypertension·J NussbergerH R Brunner
Jan 1, 1985·European Journal of Clinical Pharmacology·M D SchallerH R Brunner
Jan 1, 1967·International Journal of Neuropharmacology·B G Zimmerman, L Whitmore
Sep 1, 1984·Journal of Cardiovascular Pharmacology·H MajewskiK Starke
Feb 19, 1981·European Journal of Pharmacology·H Majewski, M J Rand
Oct 1, 1981·The Annals of Thoracic Surgery·A D BoydF C Spencer

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Citations

Dec 27, 1995·European Journal of Pharmacology·O LenzM Böhm
Feb 1, 1997·Acta Physiologica Scandinavica·T KahanP Hjemdahi
Sep 19, 2008·Journal of Cardiovascular Medicine·Gun JörneskogN Håkan Wallén
Apr 1, 1993·The American Journal of Physiology·J H SchwielerP Hjemdahl

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