PMID: 9438560Jan 23, 1998Paper

Influence of the severity of myocardial ischemia on the intensity of ascorbyl free radical release and on postischemic recovery during reperfusion

Free Radical Biology & Medicine
C VergelyL Rochette

Abstract

Ascorbyl free radical (AFR), can be considered as an atoxic and endogenous indicator of oxidative stress. The purpose of our experiments was to investigate the influence of the severity and length of ischemia on the extent of AFR release during myocardial ischemia and reperfusion. For that purpose, isolated perfused rat hearts were submitted to a global ischemia, either total (residual flow 0%) or low flow (residual flow 5%), of 20 or 60 min length. Coronary effluents were collected at different times of experimentation and analyzed with Electron Spin Resonance (ESR) spectroscopy. AFR ESR doublet (g = 2.0054, aH = 0.188 MT) was not detected in coronary effluents collected during control perfusion periods. Nevertheless, during low-flow ischemia, a weak AFR release was noted. Moreover, a sudden and massive AFR liberation was observed at the time of reperfusion: this AFR release was weaker after low-flow ischemia than after total ischemia and was enhanced when the duration of ischemia increased from 20 min to 60 min. The large liberation of AFR noticed during global total ischemia was associated with a greater depression in myocardial contractile function and a lower recovery in coronary flow. In conclusion, our study demonstrates...Continue Reading

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Citations

Oct 29, 2005·Bulletin of Experimental Biology and Medicine·O A SafonovaL V Matasova
Jun 24, 2003·Life Sciences·J J LahetL Rochette
Feb 22, 2003·Biochimica Et Biophysica Acta·Angelo Q MaurícioMarcelo Hermes-Lima
Jul 7, 2001·Free Radical Biology & Medicine·G ClermontL Rochette
Nov 13, 2004·The Journal of Nutritional Biochemistry·W R LeifertE J McMurchie
Jun 7, 2014·Biochimica Et Biophysica Acta·Luc RochetteCatherine Vergely
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Oct 30, 2007·Archives of Biochemistry and Biophysics·Alejandro K Samhan-AriasCarlos Gutiérrez-Merino
Jan 29, 2005·British Journal of Pharmacology·Simona PegoriniMariaelvina Sala
Jan 8, 2013·Molecular Nutrition & Food Research·Luc RochetteCatherine Vergely
Apr 6, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ségolène GambertPierre Athias
Sep 26, 2015·Canadian Journal of Physiology and Pharmacology·Luc RochetteCatherine Vergely
Aug 31, 2011·Critical Reviews in Clinical Laboratory Sciences·Ivan Spasojević
Mar 9, 2011·Journal of Molecular and Cellular Cardiology·Gerd HeuschRainer Schulz
Apr 4, 2014·BioMed Research International·Kou-Gi ShyuDuen-Suey Chou
Dec 10, 2009·Journal of Cardiovascular Pharmacology·Stéliana GhibuLuc Rochette
Jun 25, 2017·Interactive Cardiovascular and Thoracic Surgery·Jun GengZhenya Shen
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Nov 5, 1999·Journal of Cardiovascular Pharmacology·P DobsakL Rochette
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Andreas SkyschallyGerd Heusch
Jan 31, 2006·Molecular and Cellular Biochemistry·Ségolène GambertLuc Rochette
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C L HeapsJ L Parker
Sep 22, 2011·The Journal of Pharmacology and Experimental Therapeutics·Carole RichardCatherine Vergely
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Jul 25, 2000·Journal of Chromatography. a·J C Deutsch

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